DegronMD

Uniprot ID: Q969Z4

Source protein: Tumor necrosis factor receptor superfamily member 19L

Source gene: RELT

Class: DEG_APCC_KENBOX_2

Location: 234:238

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9792

ASA_SCORE: 96.3

COIL: 0.3662

CONS_SCORE: 0.7533

DSS_SCORE: 0.2198

HELIX: 0.6194

FCONS_SCORE: 1.2775

RIG_SCORE: 0.811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E236D	TCGA-AA-A00N	COAD	TCGA	KKENA	DEG_APCC_KENBOX_2	0.6758
p.E236D	TCGA-B5-A1MR	UCEC	TCGA	KKENA	DEG_APCC_KENBOX_2	0.6758
p.E236D	TCGA-CA-6717	COAD	TCGA	KKENA	DEG_APCC_KENBOX_2	0.6758
p.E236D	DO9876	COAD	ICGC	KKENA	DEG_APCC_KENBOX_2	0.6758
p.E236D	DO8264	COAD	ICGC	KKENA	DEG_APCC_KENBOX_2	0.6758
p.E236D	DO41758	UCEC	ICGC	KKENA	DEG_APCC_KENBOX_2	0.6758
p.E242G	TCGA-B0-5707	KIRC	TCGA	KKENA	DEG_APCC_KENBOX_2	0.2222
p.E242G	DO20733	KIRC	ICGC	KKENA	DEG_APCC_KENBOX_2	0.2222
p.R229H	TCGA-FI-A2D0	UCEC	TCGA	KKENA	DEG_APCC_KENBOX_2	0.1944
p.R229H	DO43891	UCEC	ICGC	KKENA	DEG_APCC_KENBOX_2	0.1944
p.R229L	DO229015	LICA	ICGC	KKENA	DEG_APCC_KENBOX_2	0.1944
p.L227P	DO229211	THCA	ICGC	KKENA	DEG_APCC_KENBOX_2	0.1389
p.I224T	SIDM00190	Melanoma	GDSC	KKENA	DEG_APCC_KENBOX_2	0.0556
p.I224T	SIDM01715	Non-Cancerous	GDSC	KKENA	DEG_APCC_KENBOX_2	0.0556
p.I224T	SIDM00132	Pancreatic Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	0.0556
p.I224T	SIDM01502	Endometrial Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15596	Nuclear receptor coactivator 2	DEG_APCC_KENBOX_2	739:743	KKENA	APC,CDC20,FZR1	0.856	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_APCC_KENBOX_2	670:674	KKENA	APC,CDC20,FZR1	0.9539	More...
Q969Z4	Tumor necrosis factor receptor superfamily member 19L	DEG_APCC_KENBOX_2	234:238	KKENA	APC,CDC20,FZR1	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons