DegronMD - Q15596(NCOA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A899D	TCGA-39-5040	LUSC	TCGA	NSSPYSVIP	CBL_PTK	907:915	Mutation rewiring degron network	0.1111
p.A899D	DO45436	LUSC	ICGC	NSSPYSVIP	CBL_PTK	907:915	Mutation rewiring degron network	0.1111
p.M577I	TCGA-51-6867	LUSC	TCGA	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.0833
p.M577I	DO26477	LUSC	ICGC	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.0833
p.P516A	TCGA-55-A492	LUAD	TCGA	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.P516A	DO23708	LUAD	ICGC	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.T897N	TCGA-5M-AATA	COAD	TCGA	NSSPYSVIP	CBL_PTK	907:915	Mutation rewiring degron network	0.0556
p.T897N	DO228986	LICA	ICGC	NSSPYSVIP	CBL_PTK	907:915	Mutation rewiring degron network	0.0556
p.P910L	TCGA-77-7463	LUSC	TCGA	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.6471
p.P910L	DO26716	LUSC	ICGC	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.6471
p.E601Q	TCGA-77-8136	LUSC	TCGA	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.0556
p.E601Q	DO26593	LUSC	ICGC	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.0556
p.S958N	TCGA-90-7766	LUSC	TCGA	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1111
p.S958N	DO26722	LUSC	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1111
p.G978E	TCGA-AC-A23H	BRCA	TCGA	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1111
p.G978E	DO2401	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1111
p.F586L	TCGA-AG-A002	READ	TCGA	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation altering degron motif	0.587
p.D584Y	TCGA-B5-A1MR	UCEC	TCGA	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.2778
p.D584Y	DO41758	UCEC	ICGC	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.2778
p.R746C	TCGA-B5-A3FC	UCEC	TCGA	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.25
p.R746C	TCGA-BR-4201	STAD	TCGA	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.25
p.R746C	TCGA-WE-A8K5	SKCM	TCGA	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.25
p.R746C	DO51282	SKCM	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.25
p.R746C	DO38707	STAD	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.25
p.R746C	DO41871	UCEC	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.25
p.R974Q	TCGA-B7-A5TI	STAD	TCGA	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.2222
p.R974Q	DO222328	STAD	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.2222
p.S512R	TCGA-CA-6717	COAD	TCGA	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.S512R	DO8264	COAD	ICGC	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.T729A	TCGA-CG-4460	STAD	TCGA	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation blocking phosphorylation signal	0.5
p.T729A	DO38427	STAD	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation blocking phosphorylation signal	0.5
p.P760T	TCGA-CJ-5675	KIRC	TCGA	PEITPKLE	DEG_SCF_FBW7_2	760:767	Mutation altering degron motif	0.7031
p.P760T	DO19833	KIRC	ICGC	PEITPKLE	DEG_SCF_FBW7_2	760:767	Mutation altering degron motif	0.7031
p.P956L	TCGA-D5-6540	COAD	TCGA	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.0556
p.P956L	TCGA-MH-A561	KIRP	TCGA	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.0556
p.P956L	DO9708	COAD	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.0556
p.P956L	DO48509	KIRP	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.0556
p.P509S	TCGA-EB-A431	SKCM	TCGA	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.P509S	DO37671	SKCM	ICGC	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.P775S	TCGA-EE-A2GR	SKCM	TCGA	PEITPKLE	DEG_SCF_FBW7_2	760:767	Mutation rewiring degron network	0.1111
p.P775S	DO37996	SKCM	ICGC	PEITPKLE	DEG_SCF_FBW7_2	760:767	Mutation rewiring degron network	0.1111
p.P910S	TCGA-EE-A2M6	SKCM	TCGA	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.5641
p.P910S	DO222514	MELA	ICGC	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.5641
p.P910S	DO37976	SKCM	ICGC	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.5641
p.P516L	TCGA-ER-A19E	SKCM	TCGA	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.P516L	DO47542	SKCM	ICGC	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.V963A	TCGA-F7-A624	HNSC	TCGA	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.25
p.V963A	DO44440	HNSC	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.25
p.S959L	TCGA-FI-A2D5	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1389
p.S959L	DO233182	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1389
p.S959L	DO41331	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1389
p.V961L	TCGA-L5-A8NH	ESCA	TCGA	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1944
p.M577L	TCGA-T3-A92N	HNSC	TCGA	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.0833
p.M577L	DO219073	HNSC	ICGC	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.0833
p.A743T	DO218159	BRCA	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation altering degron motif	0.6028
p.A743T	DO230312	COCA	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation altering degron motif	0.6028
p.Q1309K	DO234186	ESAD	ICGC	PPNY	ITCH	1302:1305	Mutation rewiring degron network	0.2222
p.D750V	DO48240	ESCA	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.1389
p.D750V	DO48240	ESCA	ICGC	PEITPKLE	DEG_SCF_FBW7_2	760:767	Mutation rewiring degron network	0.0556
p.D756Y	DO233274	GACA	ICGC	PEITPKLE	DEG_SCF_FBW7_2	760:767	Mutation rewiring degron network	0.2222
p.N973K	DO229022	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.25
p.A743E	DO229032	LICA	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation altering degron motif	0.659
p.N531K	DO229032	LICA	ICGC	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1111
p.A1294E	DO229045	LICA	ICGC	PPNY	ITCH	1302:1305	Mutation rewiring degron network	0.1111
p.Q599K	DO229009	LICA	ICGC	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.1111
p.P509L	DO231754	LINC	ICGC	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.V976I	DO231851	LINC	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.1667
p.Q957H	DO230529	LUSC	ICGC	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.0833
p.P1302S	DO46352	OV	ICGC	PPNY	ITCH	1302:1305	Mutation altering degron motif	0.6752
p.G598V	DO32831	PACA	ICGC	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation rewiring degron network	0.1389
p.P1313L	DO229470	SKCA	ICGC	PPNY	ITCH	1302:1305	Mutation rewiring degron network	0.1111
p.A1296S	DO229259	THCA	ICGC	PPNY	ITCH	1302:1305	Mutation rewiring degron network	0.1667
p.P1302L	SIDM00007	Other Solid Cancers	GDSC	PPNY	ITCH	1302:1305	Mutation altering degron motif	0.7582
p.P1302L	ACH-001550	Skin Cancer	CCLE	PPNY	ITCH	1302:1305	Mutation altering degron motif	0.7582
p.P1302L	MCC13	skin	COSMIC	PPNY	ITCH	1302:1305	Mutation altering degron motif	0.7582
p.K738R	SIDM00151	Ovarian Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.3056
p.K738R	ACH-000966	Ovarian Cancer	CCLE	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.3056
p.K738R	IGROV-1	ovary	COSMIC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.3056
p.S533P	SIDM00217	Colorectal Carcinoma	GDSC	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.S533P	ACH-000999	Colon/Colorectal Cancer	CCLE	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.S533P	SNU-1040	large intestine	COSMIC	VCSST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.F1301V	SIDM01001	Breast Carcinoma	GDSC	PPNY	ITCH	1302:1305	Mutation rewiring degron network	0.3056
p.F1301V	ACH-000258	Breast Cancer	CCLE	PPNY	ITCH	1302:1305	Mutation rewiring degron network	0.3056
p.F1301V	DU-4475	breast	COSMIC	PPNY	ITCH	1302:1305	Mutation rewiring degron network	0.3056
p.E733V	SIDM01449	Pancreatic Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.1667
p.E733V	ACH-000517	Pancreatic Cancer	CCLE	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.1667
p.T897A	SIDM01316	Ewing's Sarcoma	GDSC	NSSPYSVIP	CBL_PTK	907:915	Mutation rewiring degron network	0.0556
p.T897A	ACH-000041	Bone Cancer	CCLE	NSSPYSVIP	CBL_PTK	907:915	Mutation rewiring degron network	0.0556
p.R962T	ACH-001521	Skin Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.2222

Kaplan plot for NCOA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCOA2

UniProt ID: Q15596

Entrez ID: 10499

Protein name: Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCOA2 in