DegronMD - Q15596(NCOA2)

FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:8670870, PubMed:23508108, PubMed:9430642). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:8670870, PubMed:23508108, PubMed:9430642). Required with NC... View more >>

GO - Biological processes (BP): cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA... View more >>

GO - Molecular function (MF): aryl hydrocarbon receptor binding [GO:0017162]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1302L	SIDM00007	Other Solid Cancers	GDSC	PPNY	ITCH	1302:1305	Mutation altering degron motif	0.7582
p.P1302L	ACH-001550	Skin Cancer	CCLE	PPNY	ITCH	1302:1305	Mutation altering degron motif	0.7582
p.P1302L	MCC13	skin	COSMIC	PPNY	ITCH	1302:1305	Mutation altering degron motif	0.7582
p.P760T	TCGA-CJ-5675	KIRC	TCGA	PEITPKLE	DEG_SCF_FBW7_2	760:767	Mutation altering degron motif	0.7031
p.P760T	DO19833	KIRC	ICGC	PEITPKLE	DEG_SCF_FBW7_2	760:767	Mutation altering degron motif	0.7031
p.P1302S	DO46352	OV	ICGC	PPNY	ITCH	1302:1305	Mutation altering degron motif	0.6752
p.A743E	DO229032	LICA	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation altering degron motif	0.659
p.P910L	TCGA-77-7463	LUSC	TCGA	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.6471
p.P910L	DO26716	LUSC	ICGC	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.6471
p.A743T	DO218159	BRCA	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation altering degron motif	0.6028
p.A743T	DO230312	COCA	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation altering degron motif	0.6028
p.F586L	TCGA-AG-A002	READ	TCGA	FGLYGE	LIG_APCC_ABBA_1	586:591	Mutation altering degron motif	0.587
p.P910S	TCGA-EE-A2M6	SKCM	TCGA	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.5641
p.P910S	DO222514	MELA	ICGC	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.5641
p.P910S	DO37976	SKCM	ICGC	NSSPYSVIP	CBL_PTK	907:915	Mutation altering degron motif	0.5641
p.T729A	TCGA-CG-4460	STAD	TCGA	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation blocking phosphorylation signal	0.5
p.T729A	DO38427	STAD	ICGC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation blocking phosphorylation signal	0.5
p.K738R	SIDM00151	Ovarian Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.3056
p.K738R	ACH-000966	Ovarian Cancer	CCLE	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.3056
p.K738R	IGROV-1	ovary	COSMIC	KKENA	DEG_APCC_KENBOX_2	739:743	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 89 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCOA2

UniProt ID: Q15596

Entrez ID: 10499

Protein name: Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCOA2 in