DegronMD

Uniprot ID: Q15596

Source protein: Nuclear receptor coactivator 2

Source gene: NCOA2

Class: DEG_SCF_FBW7_2

Location: 760:767

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 99.075

COIL: 0.808

CONS_SCORE: 0.5645

DSS_SCORE: 0.4718

HELIX: 0.1551

FCONS_SCORE: 1.0018

RIG_SCORE: 0.7673

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P760T	TCGA-CJ-5675	KIRC	TCGA	PEITPKLE	DEG_SCF_FBW7_2	0.7031
p.P760T	DO19833	KIRC	ICGC	PEITPKLE	DEG_SCF_FBW7_2	0.7031
p.D756Y	DO233274	GACA	ICGC	PEITPKLE	DEG_SCF_FBW7_2	0.2222
p.P775S	TCGA-EE-A2GR	SKCM	TCGA	PEITPKLE	DEG_SCF_FBW7_2	0.1111
p.P775S	DO37996	SKCM	ICGC	PEITPKLE	DEG_SCF_FBW7_2	0.1111
p.D750V	DO48240	ESCA	ICGC	PEITPKLE	DEG_SCF_FBW7_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15596	Nuclear receptor coactivator 2	DEG_SCF_FBW7_2	760:767	PEITPKLE	FBXW7	0.9978	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons