DegronMD

Uniprot ID: Q15596

Source protein: Nuclear receptor coactivator 2

Source gene: NCOA2

Class: LIG_APCC_ABBA_1

Location: 586:591

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9961

ASA_SCORE: 80.5

COIL: 0.8045

CONS_SCORE: 0.5087

DSS_SCORE: 0.5891

HELIX: 0.0818

FCONS_SCORE: 1.1538

RIG_SCORE: 0.6613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M577I	TCGA-51-6867	LUSC	TCGA	FGLYGE	LIG_APCC_ABBA_1	0.0833
p.M577I	DO26477	LUSC	ICGC	FGLYGE	LIG_APCC_ABBA_1	0.0833
p.E601Q	TCGA-77-8136	LUSC	TCGA	FGLYGE	LIG_APCC_ABBA_1	0.0556
p.E601Q	DO26593	LUSC	ICGC	FGLYGE	LIG_APCC_ABBA_1	0.0556
p.F586L	TCGA-AG-A002	READ	TCGA	FGLYGE	LIG_APCC_ABBA_1	0.587
p.D584Y	TCGA-B5-A1MR	UCEC	TCGA	FGLYGE	LIG_APCC_ABBA_1	0.2778
p.D584Y	DO41758	UCEC	ICGC	FGLYGE	LIG_APCC_ABBA_1	0.2778
p.M577L	TCGA-T3-A92N	HNSC	TCGA	FGLYGE	LIG_APCC_ABBA_1	0.0833
p.M577L	DO219073	HNSC	ICGC	FGLYGE	LIG_APCC_ABBA_1	0.0833
p.Q599K	DO229009	LICA	ICGC	FGLYGE	LIG_APCC_ABBA_1	0.1111
p.G598V	DO32831	PACA	ICGC	FGLYGE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15596	Nuclear receptor coactivator 2	LIG_APCC_ABBA_1	586:591	FGLYGE	APC,CDC20,FZR1	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons