DegronMD

Uniprot ID: Q15596

Source protein: Nuclear receptor coactivator 2

Source gene: NCOA2

Class: DEG_APCC_KENBOX_2

Location: 739:743

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.856

ASA_SCORE: 100.78

COIL: 0.4014

CONS_SCORE: 0.6136

DSS_SCORE: 0.4529

HELIX: 0.617

FCONS_SCORE: 0.9936

RIG_SCORE: 0.7487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R746C	TCGA-B5-A3FC	UCEC	TCGA	KKENA	DEG_APCC_KENBOX_2	0.25
p.R746C	TCGA-BR-4201	STAD	TCGA	KKENA	DEG_APCC_KENBOX_2	0.25
p.R746C	TCGA-WE-A8K5	SKCM	TCGA	KKENA	DEG_APCC_KENBOX_2	0.25
p.R746C	DO51282	SKCM	ICGC	KKENA	DEG_APCC_KENBOX_2	0.25
p.R746C	DO38707	STAD	ICGC	KKENA	DEG_APCC_KENBOX_2	0.25
p.R746C	DO41871	UCEC	ICGC	KKENA	DEG_APCC_KENBOX_2	0.25
p.T729A	TCGA-CG-4460	STAD	TCGA	KKENA	DEG_APCC_KENBOX_2	0.5
p.T729A	DO38427	STAD	ICGC	KKENA	DEG_APCC_KENBOX_2	0.5
p.A743T	DO218159	BRCA	ICGC	KKENA	DEG_APCC_KENBOX_2	0.6028
p.A743T	DO230312	COCA	ICGC	KKENA	DEG_APCC_KENBOX_2	0.6028
p.D750V	DO48240	ESCA	ICGC	KKENA	DEG_APCC_KENBOX_2	0.1389
p.A743E	DO229032	LICA	ICGC	KKENA	DEG_APCC_KENBOX_2	0.659
p.K738R	SIDM00151	Ovarian Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	0.3056
p.K738R	ACH-000966	Ovarian Cancer	CCLE	KKENA	DEG_APCC_KENBOX_2	0.3056
p.K738R	IGROV-1	ovary	COSMIC	KKENA	DEG_APCC_KENBOX_2	0.3056
p.E733V	SIDM01449	Pancreatic Carcinoma	GDSC	KKENA	DEG_APCC_KENBOX_2	0.1667
p.E733V	ACH-000517	Pancreatic Cancer	CCLE	KKENA	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15596	Nuclear receptor coactivator 2	DEG_APCC_KENBOX_2	739:743	KKENA	APC,CDC20,FZR1	0.856	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_APCC_KENBOX_2	670:674	KKENA	APC,CDC20,FZR1	0.9539	More...
Q969Z4	Tumor necrosis factor receptor superfamily member 19L	DEG_APCC_KENBOX_2	234:238	KKENA	APC,CDC20,FZR1	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons