DegronMD

Uniprot ID: Q15596

Source protein: Nuclear receptor coactivator 2

Source gene: NCOA2

Class: DEG_SPOP_SBC_1

Location: 519:523

E3 ligase: SPOP

DEGRON score: 0.7796

ASA_SCORE: 73.98

COIL: 0.8646

CONS_SCORE: 0.5715

DSS_SCORE: 0.4475

HELIX: 0.0364

FCONS_SCORE: 1.0183

RIG_SCORE: 0.6254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P516A	TCGA-55-A492	LUAD	TCGA	VCSST	DEG_SPOP_SBC_1	0.25
p.P516A	DO23708	LUAD	ICGC	VCSST	DEG_SPOP_SBC_1	0.25
p.S512R	TCGA-CA-6717	COAD	TCGA	VCSST	DEG_SPOP_SBC_1	0.1389
p.S512R	DO8264	COAD	ICGC	VCSST	DEG_SPOP_SBC_1	0.1389
p.P509S	TCGA-EB-A431	SKCM	TCGA	VCSST	DEG_SPOP_SBC_1	0.0556
p.P509S	DO37671	SKCM	ICGC	VCSST	DEG_SPOP_SBC_1	0.0556
p.P516L	TCGA-ER-A19E	SKCM	TCGA	VCSST	DEG_SPOP_SBC_1	0.25
p.P516L	DO47542	SKCM	ICGC	VCSST	DEG_SPOP_SBC_1	0.25
p.N531K	DO229032	LICA	ICGC	VCSST	DEG_SPOP_SBC_1	0.1111
p.P509L	DO231754	LINC	ICGC	VCSST	DEG_SPOP_SBC_1	0.0556
p.S533P	SIDM00217	Colorectal Carcinoma	GDSC	VCSST	DEG_SPOP_SBC_1	0.0556
p.S533P	ACH-000999	Colon/Colorectal Cancer	CCLE	VCSST	DEG_SPOP_SBC_1	0.0556
p.S533P	SNU-1040	large_intestine	COSMIC	VCSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15596	Nuclear receptor coactivator 2	DEG_SPOP_SBC_1	519:523	VCSST	SPOP	0.7796	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1101:1105	VCSST	SPOP	0.8141	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons