DegronMD

Uniprot ID: Q9ULH0

Source protein: Kinase D-interacting substrate of 220 kDa

Source gene: KIDINS220

Class: DEG_SPOP_SBC_1

Location: 1101:1105

E3 ligase: SPOP

DEGRON score: 0.8141

ASA_SCORE: 70.56

COIL: 0.8586

CONS_SCORE: 0.2903

DSS_SCORE: 0.4615

HELIX: 0.0844

FCONS_SCORE: 0.8811

RIG_SCORE: 0.6548

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1112T	TCGA-A5-A0G2	UCEC	TCGA	VCSST	DEG_SPOP_SBC_1	0.1389
p.A1112T	DO232761	PBCA	ICGC	VCSST	DEG_SPOP_SBC_1	0.1389
p.A1112T	DO41235	UCEC	ICGC	VCSST	DEG_SPOP_SBC_1	0.1389
p.T1105M	TCGA-AD-A5EJ	COAD	TCGA	VCSST	DEG_SPOP_SBC_1	0.7423
p.T1105M	DO50090	COAD	ICGC	VCSST	DEG_SPOP_SBC_1	0.7423
p.P1099Q	TCGA-B0-5701	KIRC	TCGA	VCSST	DEG_SPOP_SBC_1	0.2778
p.P1099Q	DO16240	KIRC	ICGC	VCSST	DEG_SPOP_SBC_1	0.2778
p.S1096N	TCGA-BH-A0HF	BRCA	TCGA	VCSST	DEG_SPOP_SBC_1	0.1944
p.S1096N	DO1749	BRCA	ICGC	VCSST	DEG_SPOP_SBC_1	0.1944
p.Q1097H	TCGA-EE-A2GT	SKCM	TCGA	VCSST	DEG_SPOP_SBC_1	0.2222
p.Q1097H	DO37946	SKCM	ICGC	VCSST	DEG_SPOP_SBC_1	0.2222
p.S1106P	DO230309	COCA	ICGC	VCSST	DEG_SPOP_SBC_1	0.3056
p.T1105K	DO228971	LICA	ICGC	VCSST	DEG_SPOP_SBC_1	0.7306
p.G1094V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCSST	DEG_SPOP_SBC_1	0.1389
p.G1094V	ACH-002272	Lymphoma	CCLE	VCSST	DEG_SPOP_SBC_1	0.1389
p.G1094V	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VCSST	DEG_SPOP_SBC_1	0.1389
p.Y1095F	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VCSST	DEG_SPOP_SBC_1	0.1667
p.Y1095F	ACH-002256	Leukemia	CCLE	VCSST	DEG_SPOP_SBC_1	0.1667
p.Y1095F	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VCSST	DEG_SPOP_SBC_1	0.1667
p.N1108S	SIDM00477	Esophageal Carcinoma	GDSC	VCSST	DEG_SPOP_SBC_1	0.25
p.N1108S	SIDM01700	Hodgkin's Lymphoma	GDSC	VCSST	DEG_SPOP_SBC_1	0.25
p.V1101M	SIDM00596	Endometrial Carcinoma	GDSC	VCSST	DEG_SPOP_SBC_1	0.7208
p.V1101M	SIDM01774	Pancreatic Carcinoma	GDSC	VCSST	DEG_SPOP_SBC_1	0.7208
p.V1101M	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VCSST	DEG_SPOP_SBC_1	0.7208
p.V1101M	HEC-1	endometrium	COSMIC	VCSST	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15596	Nuclear receptor coactivator 2	DEG_SPOP_SBC_1	519:523	VCSST	SPOP	0.7796	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1101:1105	VCSST	SPOP	0.8141	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VCSST

Degron related mutations and impact score

Drug responses associated with KIDINS220 mutations

All proteins holding degron of VCSST