DegronMD - Q9ULH0(KIDINS220)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1583L	TCGA-06-5416	GBM	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.2778
p.S1583L	DO10880	GBM	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.2778
p.A1392S	TCGA-37-4141	LUSC	TCGA	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.0833
p.A1392S	DO26862	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.0833
p.A1112T	TCGA-A5-A0G2	UCEC	TCGA	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1389
p.A1112T	DO232761	PBCA	ICGC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1389
p.A1112T	DO41235	UCEC	ICGC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1389
p.R1409I	TCGA-AA-A010	COAD	TCGA	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.2222
p.T1105M	TCGA-AD-A5EJ	COAD	TCGA	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7423
p.T1105M	DO50090	COAD	ICGC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7423
p.S1590Y	TCGA-AP-A1DV	UCEC	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation altering degron motif	0.712
p.S1590Y	DO43186	UCEC	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation altering degron motif	0.712
p.H1597Q	TCGA-AX-A06F	UCEC	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.1667
p.H1597Q	DO41752	UCEC	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.1667
p.P1099Q	TCGA-B0-5701	KIRC	TCGA	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.2778
p.P1099Q	DO16240	KIRC	ICGC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.2778
p.S1096N	TCGA-BH-A0HF	BRCA	TCGA	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1944
p.S1096N	DO1749	BRCA	ICGC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1944
p.S1594Y	TCGA-CA-6717	COAD	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation blocking phosphorylation signal	0.6944
p.S1594Y	DO8264	COAD	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation blocking phosphorylation signal	0.6944
p.Q1097H	TCGA-EE-A2GT	SKCM	TCGA	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.2222
p.Q1097H	DO37946	SKCM	ICGC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.2222
p.G1402R	TCGA-EO-A22U	UCEC	TCGA	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation altering degron motif	0.6457
p.G1402R	DO43755	UCEC	ICGC	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation altering degron motif	0.6457
p.A1576V	TCGA-HU-A4GX	STAD	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.0833
p.A1576V	DO47757	STAD	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.0833
p.S1407I	TCGA-WE-A8ZX	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.2778
p.S1407I	DO51291	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.2778
p.N1601S	TCGA-ZB-A96M	THYM	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.0556
p.S1106P	DO230309	COCA	ICGC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.3056
p.T1105K	DO228971	LICA	ICGC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7306
p.L1578R	DO23428	LINC	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.1389
p.N1596D	DO28024	OV	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.1944
p.S1584L	SIDM01043	Other Sarcomas	GDSC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.3056
p.S1584L	ACH-000913	Endometrial/Uterine Cancer	CCLE	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.3056
p.S1584L	ESS-1	endometrium	COSMIC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.3056
p.G1094V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1389
p.G1094V	ACH-002272	Lymphoma	CCLE	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1389
p.G1094V	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1389
p.P1401T	SIDM00845	Burkitt's Lymphoma	GDSC	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation altering degron motif	0.7031
p.Y1095F	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1667
p.Y1095F	ACH-002256	Leukemia	CCLE	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1667
p.Y1095F	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.1667
p.N1108S	SIDM00477	Esophageal Carcinoma	GDSC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.25
p.N1108S	SIDM01700	Hodgkin's Lymphoma	GDSC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation rewiring degron network	0.25
p.D1582E	SIDM00879	Breast Carcinoma	GDSC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.25
p.D1582E	ACH-000349	Breast Cancer	CCLE	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.25
p.D1582E	HCC1500	breast	COSMIC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation rewiring degron network	0.25
p.V1101M	SIDM00596	Endometrial Carcinoma	GDSC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7208
p.V1101M	SIDM01774	Pancreatic Carcinoma	GDSC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7208
p.V1101M	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7208
p.V1101M	HEC-1	endometrium	COSMIC	VCSST	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7208
p.S1590F	SIDM00783	Colorectal Carcinoma	GDSC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation altering degron motif	0.7982
p.S1590F	ACH-000971	Colon/Colorectal Cancer	CCLE	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation altering degron motif	0.7982
p.S1590F	HCT-116	large intestine	COSMIC	DSGVRSS	DEG_SCF_TRCP1_1	1585:1591	Mutation altering degron motif	0.7982
p.M1399I	NCI-H250	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	1401:1405	Mutation rewiring degron network	0.2778

Kaplan plot for KIDINS220 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIDINS220

UniProt ID: Q9ULH0

Entrez ID: 57498

Protein name: Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIDINS220 in