DegronMD

Uniprot ID: Q9ULH0

Source protein: Kinase D-interacting substrate of 220 kDa

Source gene: KIDINS220

Class: DEG_SCF_TRCP1_1

Location: 1585:1591

E3 ligase: BTRC

DEGRON score: 0.9981

ASA_SCORE: 81.2857

COIL: 0.8447

CONS_SCORE: 0.4097

DSS_SCORE: 0.6583

HELIX: 0.064

FCONS_SCORE: 1.1576

RIG_SCORE: 0.553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1583L	TCGA-06-5416	GBM	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	0.2778
p.S1583L	DO10880	GBM	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	0.2778
p.S1590Y	TCGA-AP-A1DV	UCEC	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	0.712
p.S1590Y	DO43186	UCEC	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	0.712
p.H1597Q	TCGA-AX-A06F	UCEC	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	0.1667
p.H1597Q	DO41752	UCEC	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	0.1667
p.S1594Y	TCGA-CA-6717	COAD	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	0.6944
p.S1594Y	DO8264	COAD	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	0.6944
p.A1576V	TCGA-HU-A4GX	STAD	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	0.0833
p.A1576V	DO47757	STAD	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	0.0833
p.N1601S	TCGA-ZB-A96M	THYM	TCGA	DSGVRSS	DEG_SCF_TRCP1_1	0.0556
p.L1578R	DO23428	LINC	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	0.1389
p.N1596D	DO28024	OV	ICGC	DSGVRSS	DEG_SCF_TRCP1_1	0.1944
p.S1584L	SIDM01043	Other Sarcomas	GDSC	DSGVRSS	DEG_SCF_TRCP1_1	0.3056
p.S1584L	ACH-000913	Endometrial/Uterine Cancer	CCLE	DSGVRSS	DEG_SCF_TRCP1_1	0.3056
p.S1584L	ESS-1	endometrium	COSMIC	DSGVRSS	DEG_SCF_TRCP1_1	0.3056
p.D1582E	SIDM00879	Breast Carcinoma	GDSC	DSGVRSS	DEG_SCF_TRCP1_1	0.25
p.D1582E	ACH-000349	Breast Cancer	CCLE	DSGVRSS	DEG_SCF_TRCP1_1	0.25
p.D1582E	HCC1500	breast	COSMIC	DSGVRSS	DEG_SCF_TRCP1_1	0.25
p.S1590F	SIDM00783	Colorectal Carcinoma	GDSC	DSGVRSS	DEG_SCF_TRCP1_1	0.7982
p.S1590F	ACH-000971	Colon/Colorectal Cancer	CCLE	DSGVRSS	DEG_SCF_TRCP1_1	0.7982
p.S1590F	HCT-116	large_intestine	COSMIC	DSGVRSS	DEG_SCF_TRCP1_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SCF_TRCP1_1	1585:1591	DSGVRSS	BTRC	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons