DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NSSPYSVIP
Uniprot ID:
Q15596
Source protein:
Nuclear receptor coactivator 2
Source gene:
NCOA2
Class:
CBL_PTK
Location:
907:915
E3 ligase:
CBL
DEGRON score:
0.9874
ASA_SCORE:
81.5222
COIL:
0.936
CONS_SCORE:
0.5219
DSS_SCORE:
0.5871
HELIX:
0.0223
FCONS_SCORE:
0.943
RIG_SCORE:
0.6848
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A899D
TCGA-39-5040
LUSC
TCGA
NSSPYSVIP
CBL_PTK
0.1111
p.A899D
DO45436
LUSC
ICGC
NSSPYSVIP
CBL_PTK
0.1111
p.T897N
TCGA-5M-AATA
COAD
TCGA
NSSPYSVIP
CBL_PTK
0.0556
p.T897N
DO228986
LICA
ICGC
NSSPYSVIP
CBL_PTK
0.0556
p.P910L
TCGA-77-7463
LUSC
TCGA
NSSPYSVIP
CBL_PTK
0.6471
p.P910L
DO26716
LUSC
ICGC
NSSPYSVIP
CBL_PTK
0.6471
p.P910S
TCGA-EE-A2M6
SKCM
TCGA
NSSPYSVIP
CBL_PTK
0.5641
p.P910S
DO222514
MELA
ICGC
NSSPYSVIP
CBL_PTK
0.5641
p.P910S
DO37976
SKCM
ICGC
NSSPYSVIP
CBL_PTK
0.5641
p.T897A
SIDM01316
Ewing's Sarcoma
GDSC
NSSPYSVIP
CBL_PTK
0.0556
p.T897A
ACH-000041
Bone Cancer
CCLE
NSSPYSVIP
CBL_PTK
0.0556
Drug responses associated with NCOA2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSSPYSVIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15596
Nuclear receptor coactivator 2
CBL_PTK
907:915
NSSPYSVIP
CBL
0.9874
More...
