DegronMD

Uniprot ID: Q5TCQ9

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Source gene: MAGI3

Class: DEG_APCC_KENBOX_2

Location: 856:860

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9466

ASA_SCORE: 119.96

COIL: 0.6088

CONS_SCORE: 0.4735

DSS_SCORE: 0.3416

HELIX: 0.0178

FCONS_SCORE: 1.5116

RIG_SCORE: 0.7487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G863D	TCGA-06-5416	GBM	TCGA	RKENE	DEG_APCC_KENBOX_2	0.25
p.G863D	DO10880	GBM	ICGC	RKENE	DEG_APCC_KENBOX_2	0.25
p.L854S	TCGA-AA-3977	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.2778
p.L854S	DO8730	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2778
p.T868A	TCGA-BR-7707	STAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1111
p.T868A	DO38487	STAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1111
p.R856Q	TCGA-FS-A1ZC	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	0.6218
p.R856Q	DO37487	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	0.6218
p.T868I	TCGA-W3-AA1V	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	0.1111
p.T868I	DO51276	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1111
p.E858D	DO8264	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.6758
p.D851N	DO228890	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.1944
p.V852F	DO229006	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2222
p.T853K	NB12	autonomic_ganglia	COSMIC	RKENE	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14966	Zinc finger protein 638	DEG_APCC_KENBOX_2	478:482	RKENE	APC,CDC20,FZR1	0.7217	More...
Q15170	Transcription elongation factor A protein-like 1	DEG_APCC_KENBOX_2	5:9	RKENE	APC,CDC20,FZR1	0.9469	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_APCC_KENBOX_2	856:860	RKENE	APC,CDC20,FZR1	0.9466	More...
Q8IUC8	Polypeptide N-acetylgalactosaminyltransferase 13	DEG_APCC_KENBOX_2	447:451	RKENE	APC,CDC20,FZR1	0.5702	More...
Q8N3J5	Protein phosphatase 1K, mitochondrial	DEG_APCC_KENBOX_2	104:108	RKENE	APC,CDC20,FZR1	0.9571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons