DegronMD - Q8N3J5(PPM1K)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A98T	TCGA-5M-AAT4	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	TCGA-AZ-6598	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	TCGA-R6-A6DN	ESCA	TCGA	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	DO10276	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	DO223702	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	SIDM00305	Ovarian Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	SIDM00220	Ovarian Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	ACH-001145	Ovarian Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	ACH-001513	Cervical Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A98T	JHOS-2	ovary	COSMIC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.R110L	TCGA-AP-A1E0	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2778
p.R110L	DO43154	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2778
p.R110W	TCGA-DU-6392	LGG	TCGA	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2778
p.R110W	DO22237	LGG	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2778
p.A114V	TCGA-FI-A2D5	UCEC	TCGA	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A114V	DO41331	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.E106K	TCGA-FR-A69P	SKCM	TCGA	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.7022
p.E106K	DO47292	SKCM	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.7022
p.G102A	TCGA-P3-A6SX	HNSC	TCGA	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2778
p.G102A	DO49051	HNSC	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2778
p.A114T	DO9876	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.A114T	DO23258	LINC	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1667
p.F113L	DO229022	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1944
p.D112E	DO229026	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2222
p.D112E	DO229045	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2222
p.A104D	DO229031	LICA	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.7793
p.A106V	DO43186	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.6936
p.A106V	DO52402	UCEC	ICGC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.6936
p.A106V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.6936
p.R104W	SIDM02035	Colorectal Carcinoma	GDSC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.7523
p.R104W	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.7523
p.G102S	ACH-001645	Skin Cancer	CCLE	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2778
p.A104T	CAL-51	breast	COSMIC	RKENE	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPM1K

UniProt ID: Q8N3J5

Entrez ID: 152926

Protein name: Protein phosphatase 1K, mitochondrial (EC 3.1.3.16) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C isoform kappa) (PP2C-kappa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPM1K in