DegronMD

Uniprot ID: Q15170

Source protein: Transcription elongation factor A protein-like 1

Source gene: TCEAL1

Class: DEG_APCC_KENBOX_2

Location: 5:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9469

ASA_SCORE: 127.48

COIL: 0.7734

CONS_SCORE: 0.7191

DSS_SCORE: 0.9397

HELIX: 0.2344

FCONS_SCORE: 1.0284

RIG_SCORE: 0.564

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4T	TCGA-OR-A5KB	ACC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.75
p.S14R	ACH-001977	Primary	CCLE	RKENE	DEG_APCC_KENBOX_2	0.6389
p.P12L	TCGA-A6-3809	COAD	TCGA	RKENE	DEG_APCC_KENBOX_2	0.25
p.P12L	TCGA-EK-A2RK	CESC	TCGA	RKENE	DEG_APCC_KENBOX_2	0.25
p.P12L	DO49952	CESC	ICGC	RKENE	DEG_APCC_KENBOX_2	0.25
p.P12L	DO8722	COAD	ICGC	RKENE	DEG_APCC_KENBOX_2	0.25
p.Q13K	DO229234	THCA	ICGC	RKENE	DEG_APCC_KENBOX_2	0.2222

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_APCC_KENBOX_2	856:860	RKENE	APC,CDC20,FZR1	0.9466	More...
Q8IUC8	Polypeptide N-acetylgalactosaminyltransferase 13	DEG_APCC_KENBOX_2	447:451	RKENE	APC,CDC20,FZR1	0.5702	More...
Q8N3J5	Protein phosphatase 1K, mitochondrial	DEG_APCC_KENBOX_2	104:108	RKENE	APC,CDC20,FZR1	0.9571	More...
Q15170	Transcription elongation factor A protein-like 1	DEG_APCC_KENBOX_2	5:9	RKENE	APC,CDC20,FZR1	0.9469	More...
Q14966	Zinc finger protein 638	DEG_APCC_KENBOX_2	478:482	RKENE	APC,CDC20,FZR1	0.7217	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons