DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RKENE
Uniprot ID:
Q15170
Source protein:
Transcription elongation factor A protein-like 1
Source gene:
TCEAL1
Class:
DEG_APCC_KENBOX_2
Location:
5:9
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9469
ASA_SCORE:
127.48
COIL:
0.7734
CONS_SCORE:
0.7191
DSS_SCORE:
0.9397
HELIX:
0.2344
FCONS_SCORE:
1.0284
RIG_SCORE:
0.564
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P12L
TCGA-A6-3809
COAD
TCGA
RKENE
DEG_APCC_KENBOX_2
0.25
p.P12L
TCGA-EK-A2RK
CESC
TCGA
RKENE
DEG_APCC_KENBOX_2
0.25
p.P12L
DO49952
CESC
ICGC
RKENE
DEG_APCC_KENBOX_2
0.25
p.P12L
DO8722
COAD
ICGC
RKENE
DEG_APCC_KENBOX_2
0.25
p.P4T
TCGA-OR-A5KB
ACC
TCGA
RKENE
DEG_APCC_KENBOX_2
0.75
p.Q13K
DO229234
THCA
ICGC
RKENE
DEG_APCC_KENBOX_2
0.2222
p.S14R
ACH-001977
Primary
CCLE
RKENE
DEG_APCC_KENBOX_2
0.6389
Drug responses associated with TCEAL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RKENE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14966
Zinc finger protein 638
DEG_APCC_KENBOX_2
478:482
RKENE
APC,CDC20,FZR1
0.7217
More...
Q15170
Transcription elongation factor A protein-like 1
DEG_APCC_KENBOX_2
5:9
RKENE
APC,CDC20,FZR1
0.9469
More...
Q5TCQ9
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
DEG_APCC_KENBOX_2
856:860
RKENE
APC,CDC20,FZR1
0.9466
More...
Q8IUC8
Polypeptide N-acetylgalactosaminyltransferase 13
DEG_APCC_KENBOX_2
447:451
RKENE
APC,CDC20,FZR1
0.5702
More...
Q8N3J5
Protein phosphatase 1K, mitochondrial
DEG_APCC_KENBOX_2
104:108
RKENE
APC,CDC20,FZR1
0.9571
More...