DegronMD

Uniprot ID: Q8IUC8

Source protein: Polypeptide N-acetylgalactosaminyltransferase 13

Source gene: GALNT13

Class: DEG_APCC_DBOX_1

Location: 510:518

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8765

ASA_SCORE: 76.1667

COIL: 0.5423

CONS_SCORE: 0.4022

DSS_SCORE: 0.2733

HELIX: 0.0174

FCONS_SCORE: 0.7919

RIG_SCORE: 0.7942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R515Q	TCGA-31-1950	OV	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	0.6218
p.R515Q	DO30980	OV	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.6218
p.P526T	TCGA-44-2655	LUAD	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	0.1111
p.P526T	DO23557	LUAD	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.1111
p.E510D	TCGA-55-7907	LUAD	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	0.5647
p.E510D	DO25396	LUAD	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.5647
p.G501V	TCGA-AX-A2HC	UCEC	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	0.0833
p.G501V	DO41572	UCEC	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.0833
p.S527F	TCGA-B5-A0JY	UCEC	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	0.0833
p.S527F	DO43041	UCEC	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.0833
p.G501A	TCGA-CJ-6033	KIRC	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	0.0833
p.G501A	DO16881	KIRC	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.0833
p.D524H	TCGA-DU-7300	LGG	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	0.1667
p.D524H	DO22684	LGG	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.1667
p.G501R	TCGA-Q9-A6FW	ESCA	TCGA	ERLTLRHVN	DEG_APCC_DBOX_1	0.0833
p.L523I	DO222421	BTCA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.1944
p.V515L	DO228986	LICA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.6765
p.S511F	DO222418	MELA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.7982
p.G501E	DO222880	MELA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.0833
p.D508N	DO219878	SKCA	ICGC	ERLTLRHVN	DEG_APCC_DBOX_1	0.2778
p.N520S	ACH-000534	Lymphoma	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	0.2778
p.N520S	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	ERLTLRHVN	DEG_APCC_DBOX_1	0.2778
p.T513R	ACH-000554	Breast Cancer	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	0.6765
p.T513R	UACC-893	breast	COSMIC	ERLTLRHVN	DEG_APCC_DBOX_1	0.6765
p.N518S	ACH-001610	Brain Cancer	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	0.5958
p.H516R	ACH-001853	Bile Duct Cancer	CCLE	ERLTLRHVN	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUC8	Polypeptide N-acetylgalactosaminyltransferase 13	DEG_APCC_DBOX_1	510:518	ERLTLRHVN	APC,CDC20,FZR1	0.8765	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERLTLRHVN

Degron related mutations and impact score

Drug responses associated with GALNT13 mutations

All proteins holding degron of ERLTLRHVN