DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PKSTT
Uniprot ID:
Q14966
Source protein:
Zinc finger protein 638
Source gene:
ZNF638
Class:
DEG_SPOP_SBC_1
Location:
1518:1522
E3 ligase:
SPOP
DEGRON score:
0.7644
ASA_SCORE:
103.92
COIL:
0.917
CONS_SCORE:
0.5804
DSS_SCORE:
0.7114
HELIX:
0.0316
FCONS_SCORE:
1.0094
RIG_SCORE:
0.5844
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E1512G
TCGA-BT-A3PK
BLCA
TCGA
PKSTT
DEG_SPOP_SBC_1
0.1667
p.E1512G
DO44051
BLCA
ICGC
PKSTT
DEG_SPOP_SBC_1
0.1667
p.P1518L
TCGA-EB-A5SG
SKCM
TCGA
PKSTT
DEG_SPOP_SBC_1
0.7582
p.P1518L
DO48726
SKCM
ICGC
PKSTT
DEG_SPOP_SBC_1
0.7582
p.S1526Y
TCGA-EO-A3B0
UCEC
TCGA
PKSTT
DEG_SPOP_SBC_1
0.2222
p.S1526Y
DO219773
UCEC
ICGC
PKSTT
DEG_SPOP_SBC_1
0.2222
p.R1524S
SIDM00133
Non-Small Cell Lung Carcinoma
GDSC
PKSTT
DEG_SPOP_SBC_1
0.2778
p.R1524S
ACH-000861
Lung Cancer
CCLE
PKSTT
DEG_SPOP_SBC_1
0.2778
p.R1524S
HOP-62
lung
COSMIC
PKSTT
DEG_SPOP_SBC_1
0.2778
Drug responses associated with ZNF638 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P07359
Platelet glycoprotein Ib alpha chain
DEG_SPOP_SBC_1
376:380
PKSTT
SPOP
0.9058
More...
Q14966
Zinc finger protein 638
DEG_SPOP_SBC_1
1518:1522
PKSTT
SPOP
0.7644
More...
Q52LJ0
Protein FAM98B
DEG_SPOP_SBC_1
160:164
PKSTT
SPOP
0.9796
More...
Q9BZW7
Testis-specific gene 10 protein
DEG_SPOP_SBC_1
89:93
PKSTT
SPOP
0.765
More...
Q9UMN6
Histone-lysine N-methyltransferase 2B
DEG_SPOP_SBC_1
515:519
PKSTT
SPOP
0.9463
More...
Q9Y2R2
Tyrosine-protein phosphatase non-receptor type 22
DEG_SPOP_SBC_1
329:333
PKSTT
SPOP
0.828
More...
Q5HYC2
Uncharacterized protein KIAA2026
DEG_SPOP_SBC_1
1324:1328
PKSTT
SPOP
0.9941
More...