DegronMD

Uniprot ID: Q5HYC2

Source protein: Uncharacterized protein KIAA2026

Source gene: KIAA2026

Class: DEG_SPOP_SBC_1

Location: 1324:1328

E3 ligase: SPOP

DEGRON score: 0.9941

ASA_SCORE: 104.52

COIL: 0.9388

CONS_SCORE: 0.3909

DSS_SCORE: 0.3052

HELIX: 0.0176

FCONS_SCORE: 1.341

RIG_SCORE: 0.7189

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1328I	TCGA-B6-A0WY	BRCA	TCGA	PKSTT	DEG_SPOP_SBC_1	0.7078
p.S1326F	DO228771	GACA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.7982
p.A1332V	SIDM00660	Colorectal Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	0.2222
p.A1332V	ACH-000985	Colon/Colorectal Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	0.2222
p.A1332V	LS-411N	large_intestine	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.2222
p.Q1319H	ACH-000071	Non-Cancerous	CCLE	PKSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SPOP_SBC_1	376:380	PKSTT	SPOP	0.9058	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1518:1522	PKSTT	SPOP	0.7644	More...
Q52LJ0	Protein FAM98B	DEG_SPOP_SBC_1	160:164	PKSTT	SPOP	0.9796	More...
Q9BZW7	Testis-specific gene 10 protein	DEG_SPOP_SBC_1	89:93	PKSTT	SPOP	0.765	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	515:519	PKSTT	SPOP	0.9463	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	329:333	PKSTT	SPOP	0.828	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1324:1328	PKSTT	SPOP	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons