DegronMD - Q9BZW7(TSGA10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E102D	TCGA-55-A4DF	LUAD	TCGA	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.E102D	DO45318	LUAD	ICGC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.A94V	TCGA-AB-2833	LAML	TCGA	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.A94V	DO21679	LAML	ICGC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.T93M	TCGA-AN-A0AK	BRCA	TCGA	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.T93M	TCGA-EO-A22U	UCEC	TCGA	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.T93M	TCGA-IB-7651	PAAD	TCGA	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.T93M	DO1608	BRCA	ICGC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.T93M	DO46657	PAAD	ICGC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.T93M	DO43755	UCEC	ICGC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.T93M	SIDM02059	Colorectal Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.H95P	TCGA-D8-A1XQ	BRCA	TCGA	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2778
p.H95P	DO3095	BRCA	ICGC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2778
p.K84E	TCGA-L5-A4OG	ESCA	TCGA	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation substituting flanking lysine	0.3056
p.C86S	TCGA-QK-A8Z7	HNSC	TCGA	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.C86S	DO52096	HNSC	ICGC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.R99W	DO230326	COCA	ICGC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.R99W	SIDM00491	Thyroid Gland Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.R99W	ASH-3	thyroid	COSMIC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.S88R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.S88R	ACH-002256	Leukemia	CCLE	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.S88R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.R80Q	SIDM00537	Colorectal Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.R80Q	ACH-000982	Colon/Colorectal Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.R80Q	ACH-001345	Colon/Colorectal Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.R80Q	GP5d	large intestine	COSMIC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.H95R	SIDM01679	Small Cell Lung Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2778

Kaplan plot for TSGA10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSGA10

UniProt ID: Q9BZW7

Entrez ID: 80705

Protein name: Testis-specific gene 10 protein (Testis development protein NYD-SP7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSGA10 in