DegronMD

Uniprot ID: Q9BZW7

Source protein: Testis-specific gene 10 protein

Source gene: TSGA10

Class: DEG_SPOP_SBC_1

Location: 89:93

E3 ligase: SPOP

DEGRON score: 0.765

ASA_SCORE: 98.76

COIL: 0.5864

CONS_SCORE: 0.7333

DSS_SCORE: 0.5058

HELIX: 0.3974

FCONS_SCORE: 1.0487

RIG_SCORE: 0.6561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E102D	TCGA-55-A4DF	LUAD	TCGA	PKSTT	DEG_SPOP_SBC_1	0.0833
p.E102D	DO45318	LUAD	ICGC	PKSTT	DEG_SPOP_SBC_1	0.0833
p.A94V	TCGA-AB-2833	LAML	TCGA	PKSTT	DEG_SPOP_SBC_1	0.3056
p.A94V	DO21679	LAML	ICGC	PKSTT	DEG_SPOP_SBC_1	0.3056
p.T93M	TCGA-AN-A0AK	BRCA	TCGA	PKSTT	DEG_SPOP_SBC_1	0.7423
p.T93M	TCGA-EO-A22U	UCEC	TCGA	PKSTT	DEG_SPOP_SBC_1	0.7423
p.T93M	TCGA-IB-7651	PAAD	TCGA	PKSTT	DEG_SPOP_SBC_1	0.7423
p.T93M	DO1608	BRCA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.7423
p.T93M	DO46657	PAAD	ICGC	PKSTT	DEG_SPOP_SBC_1	0.7423
p.T93M	DO43755	UCEC	ICGC	PKSTT	DEG_SPOP_SBC_1	0.7423
p.T93M	SIDM02059	Colorectal Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	0.7423
p.H95P	TCGA-D8-A1XQ	BRCA	TCGA	PKSTT	DEG_SPOP_SBC_1	0.2778
p.H95P	DO3095	BRCA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.2778
p.K84E	TCGA-L5-A4OG	ESCA	TCGA	PKSTT	DEG_SPOP_SBC_1	0.3056
p.C86S	TCGA-QK-A8Z7	HNSC	TCGA	PKSTT	DEG_SPOP_SBC_1	0.25
p.C86S	DO52096	HNSC	ICGC	PKSTT	DEG_SPOP_SBC_1	0.25
p.R99W	DO230326	COCA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.1667
p.R99W	SIDM00491	Thyroid Gland Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	0.1667
p.R99W	ASH-3	thyroid	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.1667
p.S88R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PKSTT	DEG_SPOP_SBC_1	0.3056
p.S88R	ACH-002256	Leukemia	CCLE	PKSTT	DEG_SPOP_SBC_1	0.3056
p.S88R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.3056
p.R80Q	SIDM00537	Colorectal Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	0.0833
p.R80Q	ACH-000982	Colon/Colorectal Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	0.0833
p.R80Q	ACH-001345	Colon/Colorectal Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	0.0833
p.R80Q	GP5d	large_intestine	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.0833
p.H95R	SIDM01679	Small Cell Lung Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SPOP_SBC_1	376:380	PKSTT	SPOP	0.9058	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1518:1522	PKSTT	SPOP	0.7644	More...
Q52LJ0	Protein FAM98B	DEG_SPOP_SBC_1	160:164	PKSTT	SPOP	0.9796	More...
Q9BZW7	Testis-specific gene 10 protein	DEG_SPOP_SBC_1	89:93	PKSTT	SPOP	0.765	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	515:519	PKSTT	SPOP	0.9463	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	329:333	PKSTT	SPOP	0.828	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1324:1328	PKSTT	SPOP	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSTT

Degron related mutations and impact score

Drug responses associated with TSGA10 mutations

All proteins holding degron of PKSTT