DegronMD

Uniprot ID: Q14966

Source protein: Zinc finger protein 638

Source gene: ZNF638

Class: DEG_SPOP_SBC_1

Location: 610:614

E3 ligase: SPOP

DEGRON score: 0.8762

ASA_SCORE: 95.5

COIL: 0.926

CONS_SCORE: 0.5509

DSS_SCORE: 0.8068

HELIX: 0.0282

FCONS_SCORE: 0.9453

RIG_SCORE: 0.5423

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T612I	TCGA-36-2547	OV	TCGA	PKTSS	DEG_SPOP_SBC_1	0.8189
p.T612I	DO30990	OV	ICGC	PKTSS	DEG_SPOP_SBC_1	0.8189
p.P606Q	TCGA-BF-A1PZ	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	0.2222
p.P606Q	DO50279	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.P618S	TCGA-EB-A24D	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	0.2222
p.P618S	DO37440	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.P618L	TCGA-EB-A24D	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	0.2222
p.P618L	DO37440	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.S614N	TCGA-G4-6309	COAD	TCGA	PKTSS	DEG_SPOP_SBC_1	0.818
p.S614N	DO7810	COAD	ICGC	PKTSS	DEG_SPOP_SBC_1	0.818
p.P606S	TCGA-GF-A4EO	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	0.2222
p.P606S	DO47559	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.S605L	SIDM01577	Plasma Cell Myeloma	GDSC	PKTSS	DEG_SPOP_SBC_1	0.6389
p.S605L	ACH-000889	Myeloma	CCLE	PKTSS	DEG_SPOP_SBC_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_SPOP_SBC_1	188:192	PKTSS	SPOP	0.6385	More...
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	489:493	PKTSS	SPOP	0.8197	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	610:614	PKTSS	SPOP	0.8762	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1063:1067	PKTSS	SPOP	0.955	More...
Q6ZWJ1	Syntaxin-binding protein 4	DEG_SPOP_SBC_1	149:153	PKTSS	SPOP	0.8731	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	2822:2826	PKTSS	SPOP	0.9052	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3053:3057	PKTSS	SPOP	0.8531	More...
Q96GS4	BLOC-1-related complex subunit 6	DEG_SPOP_SBC_1	62:66	PKTSS	SPOP	0.9347	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	1141:1145	PKTSS	SPOP	0.958	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1292:1296	PKTSS	SPOP	0.6269	More...
Q9Y6B7	AP-4 complex subunit beta-1	DEG_SPOP_SBC_1	589:593	PKTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons