DegronMD - O43303(CCP110)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L588V	TCGA-55-6979	LUAD	TCGA	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.1111
p.L588V	DO24110	LUAD	ICGC	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.1111
p.T430A	TCGA-58-8391	LUSC	TCGA	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation rewiring degron network	0.1667
p.T430A	DO45440	LUSC	ICGC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation rewiring degron network	0.1667
p.E423A	TCGA-A5-A2K5	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7701
p.E423A	DO41379	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7701
p.K404Q	TCGA-AP-A1E0	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation substituting flanking lysine	0.1667
p.K404Q	DO43154	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation substituting flanking lysine	0.1667
p.R586Q	TCGA-B5-A3FA	UCEC	TCGA	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0556
p.R586Q	DO233652	GACA	ICGC	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0556
p.R586Q	DO52402	UCEC	ICGC	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0556
p.E423K	TCGA-BK-A6W3	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	TCGA-BS-A0UV	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	DO50076	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	DO42793	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00993	Plasma Cell Myeloma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00557	Neuroblastoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00373	Endometrial Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00465	Ovarian Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00296	Small Cell Lung Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00492	Glioblastoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00235	Kidney Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00526	Chronic Myelogenous Leukemia	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM01019	Acute Myeloid Leukemia	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00580	Acute Myeloid Leukemia	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00579	Neuroblastoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00543	Melanoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM00026	Other Solid Cancers	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.E423K	SIDM01570	Ovarian Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.7022
p.D578Y	TCGA-EE-A20H	SKCM	TCGA	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.1111
p.D578Y	DO37986	SKCM	ICGC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.1111
p.M408I	TCGA-FI-A2D0	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation rewiring degron network	0.1667
p.M408I	DO43891	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation rewiring degron network	0.1667
p.N573Y	TCGA-FU-A40J	CESC	TCGA	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.25
p.N573Y	DO44314	CESC	ICGC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.25
p.E610V	TCGA-HE-A5NK	KIRP	TCGA	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0556
p.E610V	DO51562	KIRP	ICGC	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0556
p.T560M	DO229005	COCA	ICGC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	DO229505	LAML	ICGC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00450	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00303	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00582	Pancreatic Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00234	Other Solid Cancers	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01197	Colorectal Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00411	Pancreatic Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00367	Small Cell Lung Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00281	Other Solid Cancers	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01005	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00569	Osteosarcoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00193	Colorectal Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00267	Biliary Tract Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00465	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00002	Neuroblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01194	Hepatocellular Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00060	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00238	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01172	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00487	Colorectal Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00375	Head and Neck Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00024	Non-Cancerous	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00488	Colorectal Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00616	Hepatocellular Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00271	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00469	Pancreatic Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00566	Oral Cavity Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01257	Hepatocellular Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00380	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00289	B-Lymphoblastic Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00316	Glioblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00274	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00279	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00531	Pancreatic Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01582	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01463	Endometrial Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01570	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00168	Head and Neck Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01498	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01470	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01749	Osteosarcoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01770	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01444	Glioblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00062	Hepatocellular Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01611	Endometrial Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01394	Kidney Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01573	Plasma Cell Myeloma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01779	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01347	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01445	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01446	Glioblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01447	Glioblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01690	Plasma Cell Myeloma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01587	Bladder Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM00016	Neuroblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01574	Plasma Cell Myeloma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.T560M	SIDM01391	Neuroblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	564:570	Mutation rewiring degron network	0.2222
p.C600R	DO233951	GACA	ICGC	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.719
p.Q413E	DO27903	ORCA	ICGC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation rewiring degron network	0.3056
p.R587G	SIDM00364	B-Lymphoblastic Leukemia	GDSC	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.R587G	ACH-002059	Leukemia	CCLE	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.R587G	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	QKENC	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.E405K	SIDM01133	Other Solid Cancers	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation rewiring degron network	0.0833
p.E405K	ACH-002177	Lung Cancer	CCLE	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation rewiring degron network	0.0833
p.E405K	NCI-H835	lung	COSMIC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation rewiring degron network	0.0833
p.D416N	SIDM00954	Breast Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.5821
p.D416N	ACH-001820	Breast Cancer	CCLE	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.5821
p.D416N	COLO-824	breast	COSMIC	DTDENTNVPEI	DEG_COP1_1	414:424	Mutation altering degron motif	0.5821

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCP110

UniProt ID: O43303

Entrez ID: 9738

Protein name: Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCP110 in