DegronMD

Uniprot ID: O43303

Source protein: Centriolar coiled-coil protein of 110 kDa

Source gene: CCP110

Class: DEG_SCF_FBW7_1

Location: 564:570

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 93.0286

COIL: 0.8743

CONS_SCORE: 0.5788

DSS_SCORE: 0.5851

HELIX: 0.074

FCONS_SCORE: 1.2939

RIG_SCORE: 0.7404

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D578Y	TCGA-EE-A20H	SKCM	TCGA	MDTPMVS	DEG_SCF_FBW7_1	0.1111
p.D578Y	DO37986	SKCM	ICGC	MDTPMVS	DEG_SCF_FBW7_1	0.1111
p.N573Y	TCGA-FU-A40J	CESC	TCGA	MDTPMVS	DEG_SCF_FBW7_1	0.25
p.N573Y	DO44314	CESC	ICGC	MDTPMVS	DEG_SCF_FBW7_1	0.25
p.T560M	DO229005	COCA	ICGC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	DO229505	LAML	ICGC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00450	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00303	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00582	Pancreatic Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00234	Other Solid Cancers	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01197	Colorectal Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00411	Pancreatic Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00367	Small Cell Lung Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00281	Other Solid Cancers	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01005	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00569	Osteosarcoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00193	Colorectal Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00267	Biliary Tract Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00465	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00002	Neuroblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01194	Hepatocellular Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00060	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00238	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01172	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00487	Colorectal Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00375	Head and Neck Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00024	Non-Cancerous	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00488	Colorectal Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00616	Hepatocellular Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00271	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00469	Pancreatic Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00566	Oral Cavity Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01257	Hepatocellular Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00380	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00289	B-Lymphoblastic Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00316	Glioblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00274	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00279	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00531	Pancreatic Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01582	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01463	Endometrial Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01570	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00168	Head and Neck Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01498	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01470	Acute Myeloid Leukemia	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01749	Osteosarcoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01770	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01444	Glioblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00062	Hepatocellular Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01611	Endometrial Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01394	Kidney Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01573	Plasma Cell Myeloma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01779	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01347	Ovarian Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01445	Gastric Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01446	Glioblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01447	Glioblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01690	Plasma Cell Myeloma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01587	Bladder Carcinoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM00016	Neuroblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01574	Plasma Cell Myeloma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222
p.T560M	SIDM01391	Neuroblastoma	GDSC	MDTPMVS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MDTPMVS

Degron related mutations and impact score

Drug responses associated with CCP110 mutations

All proteins holding degron of MDTPMVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_SCF_FBW7_1	564:570	MDTPMVS	FBXW7	0.9971	More...