DegronMD

Uniprot ID: O43303

Source protein: Centriolar coiled-coil protein of 110 kDa

Source gene: CCP110

Class: DEG_COP1_1

Location: 414:424

E3 ligase: COP1

DEGRON score: 0.8695

ASA_SCORE: 99.8364

COIL: 0.8588

CONS_SCORE: 0.3748

DSS_SCORE: 0.478

HELIX: 0.0761

FCONS_SCORE: 0.9549

RIG_SCORE: 0.7777

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T430A	TCGA-58-8391	LUSC	TCGA	DTDENTNVPEI	DEG_COP1_1	0.1667
p.T430A	DO45440	LUSC	ICGC	DTDENTNVPEI	DEG_COP1_1	0.1667
p.E423A	TCGA-A5-A2K5	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	0.7701
p.E423A	DO41379	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	0.7701
p.K404Q	TCGA-AP-A1E0	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	0.1667
p.K404Q	DO43154	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	0.1667
p.E423K	TCGA-BK-A6W3	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	TCGA-BS-A0UV	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	DO50076	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	DO42793	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00993	Plasma Cell Myeloma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00557	Neuroblastoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00373	Endometrial Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00465	Ovarian Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00296	Small Cell Lung Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00492	Glioblastoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00235	Kidney Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00526	Chronic Myelogenous Leukemia	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM01019	Acute Myeloid Leukemia	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00580	Acute Myeloid Leukemia	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00579	Neuroblastoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00543	Melanoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM00026	Other Solid Cancers	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.E423K	SIDM01570	Ovarian Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.7022
p.M408I	TCGA-FI-A2D0	UCEC	TCGA	DTDENTNVPEI	DEG_COP1_1	0.1667
p.M408I	DO43891	UCEC	ICGC	DTDENTNVPEI	DEG_COP1_1	0.1667
p.Q413E	DO27903	ORCA	ICGC	DTDENTNVPEI	DEG_COP1_1	0.3056
p.E405K	SIDM01133	Other Solid Cancers	GDSC	DTDENTNVPEI	DEG_COP1_1	0.0833
p.E405K	ACH-002177	Lung Cancer	CCLE	DTDENTNVPEI	DEG_COP1_1	0.0833
p.E405K	NCI-H835	lung	COSMIC	DTDENTNVPEI	DEG_COP1_1	0.0833
p.D416N	SIDM00954	Breast Carcinoma	GDSC	DTDENTNVPEI	DEG_COP1_1	0.5821
p.D416N	ACH-001820	Breast Cancer	CCLE	DTDENTNVPEI	DEG_COP1_1	0.5821
p.D416N	COLO-824	breast	COSMIC	DTDENTNVPEI	DEG_COP1_1	0.5821

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DTDENTNVPEI

Degron related mutations and impact score

Drug responses associated with CCP110 mutations

All proteins holding degron of DTDENTNVPEI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_COP1_1	414:424	DTDENTNVPEI	COP1	0.8695	More...