DegronMD

Uniprot ID: O43303

Source protein: Centriolar coiled-coil protein of 110 kDa

Source gene: CCP110

Class: DEG_APCC_KENBOX_2

Location: 596:600

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5806

ASA_SCORE: 104.52

COIL: 0.8602

CONS_SCORE: 0.3747

DSS_SCORE: 0.2957

HELIX: 0.1146

FCONS_SCORE: 1.0027

RIG_SCORE: 0.7736

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C600R	DO233951	GACA	ICGC	QKENC	DEG_APCC_KENBOX_2	0.719
p.L588V	TCGA-55-6979	LUAD	TCGA	QKENC	DEG_APCC_KENBOX_2	0.1111
p.L588V	DO24110	LUAD	ICGC	QKENC	DEG_APCC_KENBOX_2	0.1111
p.R587G	SIDM00364	B-Lymphoblastic Leukemia	GDSC	QKENC	DEG_APCC_KENBOX_2	0.0833
p.R587G	ACH-002059	Leukemia	CCLE	QKENC	DEG_APCC_KENBOX_2	0.0833
p.R587G	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	QKENC	DEG_APCC_KENBOX_2	0.0833
p.R586Q	TCGA-B5-A3FA	UCEC	TCGA	QKENC	DEG_APCC_KENBOX_2	0.0556
p.R586Q	DO233652	GACA	ICGC	QKENC	DEG_APCC_KENBOX_2	0.0556
p.R586Q	DO52402	UCEC	ICGC	QKENC	DEG_APCC_KENBOX_2	0.0556
p.E610V	TCGA-HE-A5NK	KIRP	TCGA	QKENC	DEG_APCC_KENBOX_2	0.0556
p.E610V	DO51562	KIRP	ICGC	QKENC	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_APCC_KENBOX_2	596:600	QKENC	APC,CDC20,FZR1	0.5806	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons