DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PKTSS
Uniprot ID:
Q96GS4
Source protein:
BLOC-1-related complex subunit 6
Source gene:
BORCS6
Class:
DEG_SPOP_SBC_1
Location:
62:66
E3 ligase:
SPOP
DEGRON score:
0.9347
ASA_SCORE:
94.16
COIL:
0.9154
CONS_SCORE:
0.4757
DSS_SCORE:
0.7139
HELIX:
0.044
FCONS_SCORE:
1.1867
RIG_SCORE:
0.5843
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G68S
SIDM01242
Melanoma
GDSC
PKTSS
DEG_SPOP_SBC_1
0.2778
p.G68S
SIDM00568
Gastric Carcinoma
GDSC
PKTSS
DEG_SPOP_SBC_1
0.2778
Drug responses associated with BORCS6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43303
Centriolar coiled-coil protein of 110 kDa
DEG_SPOP_SBC_1
188:192
PKTSS
SPOP
0.6385
More...
O43314
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
DEG_SPOP_SBC_1
489:493
PKTSS
SPOP
0.8197
More...
Q14966
Zinc finger protein 638
DEG_SPOP_SBC_1
610:614
PKTSS
SPOP
0.8762
More...
Q6ZT12
E3 ubiquitin-protein ligase UBR3
DEG_SPOP_SBC_1
1063:1067
PKTSS
SPOP
0.955
More...
Q6ZWJ1
Syntaxin-binding protein 4
DEG_SPOP_SBC_1
149:153
PKTSS
SPOP
0.8731
More...
Q8NFC6
Biorientation of chromosomes in cell division protein 1-like 1
DEG_SPOP_SBC_1
2822:2826
PKTSS
SPOP
0.9052
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
3053:3057
PKTSS
SPOP
0.8531
More...
Q96GS4
BLOC-1-related complex subunit 6
DEG_SPOP_SBC_1
62:66
PKTSS
SPOP
0.9347
More...
Q9BX26
Synaptonemal complex protein 2
DEG_SPOP_SBC_1
1141:1145
PKTSS
SPOP
0.958
More...
Q9NSI6
Bromodomain and WD repeat-containing protein 1
DEG_SPOP_SBC_1
1292:1296
PKTSS
SPOP
0.6269
More...
Q9Y6B7
AP-4 complex subunit beta-1
DEG_SPOP_SBC_1
589:593
PKTSS
SPOP
0.9969
More...