DegronMD - Q9NSI6(BRWD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D570Y	TCGA-06-5416	GBM	TCGA	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.1944
p.D570Y	TCGA-N9-A4Q7	UCS	TCGA	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.1944
p.D570Y	DO10880	GBM	ICGC	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.1944
p.E2294V	TCGA-21-1079	LUSC	TCGA	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.E2294V	DO26846	LUSC	ICGC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.R1300I	TCGA-29-2434	OV	TCGA	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation rewiring degron network	0.2222
p.R1300I	DO31360	OV	ICGC	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation rewiring degron network	0.2222
p.N1610Y	TCGA-3A-A9I9	PAAD	TCGA	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.3056
p.N1610Y	DO51679	PAAD	ICGC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.3056
p.S2273C	TCGA-60-2698	LUSC	TCGA	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.S2273C	DO26469	LUSC	ICGC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.R565Q	TCGA-A5-A1OF	UCEC	TCGA	DYR	CBL_MET	563:565	Mutation altering degron motif	0.7329
p.R565Q	DO42568	UCEC	ICGC	DYR	CBL_MET	563:565	Mutation altering degron motif	0.7329
p.R565Q	SIDM00118	Colorectal Carcinoma	GDSC	DYR	CBL_MET	563:565	Mutation altering degron motif	0.7329
p.R565Q	ACH-001081	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	563:565	Mutation altering degron motif	0.7329
p.R565Q	HCC2998	large intestine	COSMIC	DYR	CBL_MET	563:565	Mutation altering degron motif	0.7329
p.L1618I	TCGA-AA-3977	COAD	TCGA	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.2778
p.L1618I	DO8730	COAD	ICGC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.2778
p.S1555F	TCGA-AD-6895	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.1389
p.S1555F	TCGA-DM-A28H	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.1389
p.S1555F	DO8906	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.1389
p.S1555F	DO8938	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.1389
p.S2273Y	TCGA-AG-A002	READ	TCGA	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.S2273Y	TCGA-EO-A22X	UCEC	TCGA	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.S2273Y	DO43907	UCEC	ICGC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.R1626Q	TCGA-B5-A0JY	UCEC	TCGA	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.0556
p.R1626Q	DO43041	UCEC	ICGC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.0556
p.D2288N	TCGA-BR-4371	STAD	TCGA	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.2778
p.D2288N	DO38348	STAD	ICGC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.2778
p.D2287A	TCGA-BS-A0UJ	UCEC	TCGA	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.3056
p.D2287A	DO42745	UCEC	ICGC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.3056
p.A1708V	TCGA-D1-A103	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.25
p.A1708V	DO42312	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.25
p.D1287N	TCGA-D3-A8GP	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation rewiring degron network	0.1944
p.D1287N	DO51244	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation rewiring degron network	0.1944
p.S2293F	TCGA-DK-A1A3	BLCA	TCGA	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation blocking phosphorylation signal	0.5833
p.S2293F	DO558	BLCA	ICGC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation blocking phosphorylation signal	0.5833
p.D570N	TCGA-DK-A1AD	BLCA	TCGA	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.1944
p.D570N	DO459	BLCA	ICGC	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.1944
p.D570N	DO233732	GACA	ICGC	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.1944
p.R569K	TCGA-DK-A1AD	BLCA	TCGA	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.2222
p.R569K	DO459	BLCA	ICGC	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.2222
p.E2294K	TCGA-DK-A6B6	BLCA	TCGA	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.E2294K	DO48576	BLCA	ICGC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1111
p.R1558C	TCGA-FW-A3R5	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.0556
p.R1558C	DO233115	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.0556
p.R1558C	DO37406	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.0556
p.S1289I	TCGA-HC-A9TE	PRAD	TCGA	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation blocking phosphorylation signal	0.6944
p.S1289I	DO223658	PRAD	ICGC	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation blocking phosphorylation signal	0.6944
p.N573T	TCGA-ND-A4WC	UCS	TCGA	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.1111
p.R926G	TCGA-QH-A6CZ	LGG	TCGA	KKENK	DEG_APCC_KENBOX_2	914:918	Mutation rewiring degron network	0.1111
p.R926G	DO50173	LGG	ICGC	KKENK	DEG_APCC_KENBOX_2	914:918	Mutation rewiring degron network	0.1111
p.L1699P	DO228471	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.2778
p.L1699P	DO229010	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.2778
p.L1699P	DO229016	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.2778
p.L1699P	DO229003	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.2778
p.L1699P	DO229005	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.2778
p.L1699P	DO229346	LAML	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.2778
p.L1699P	DO229480	LAML	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.2778
p.L1699P	DO231114	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.2778
p.S1539C	DO222613	BTCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.1944
p.S1539C	SIDM00346	Chronic Myelogenous Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.1944
p.S1539C	SIDM01640	Acute Myeloid Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.1944
p.F560L	DO231223	LAML	ICGC	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.25
p.S1710R	DO229029	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.1944
p.A1622D	DO229037	LICA	ICGC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.1667
p.S571F	DO50869	LICA	ICGC	DYR	CBL_MET	563:565	Mutation rewiring degron network	0.1667
p.Y1603C	DO44786	LICA	ICGC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.1111
p.Y564C	DO23122	LINC	ICGC	DYR	CBL_MET	563:565	Mutation altering degron motif	0.7087
p.E1553K	DO222908	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.1944
p.T1294A	DO233292	NACA	ICGC	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation altering degron motif	0.7139
p.G1297A	DO233297	NACA	ICGC	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation rewiring degron network	0.3056
p.S1296F	DO233299	NACA	ICGC	PKTSS	DEG_SPOP_SBC_1	1292:1296	Mutation altering degron motif	0.7982
p.K914N	DO220140	SARC	ICGC	KKENK	DEG_APCC_KENBOX_2	914:918	Mutation altering degron motif	0.5806
p.S1546I	DO229275	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation altering degron motif	0.7341
p.H1706Y	SIDM01126	Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.3056
p.S1548T	SIDM01126	Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation altering degron motif	0.6005
p.K2156R	SIDM01177	B-Lymphoblastic Leukemia	GDSC	PDTSS	DEG_SPOP_SBC_1	2151:2155	Mutation rewiring degron network	0.3056
p.K2156R	SIDM00731	Small Cell Lung Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	2151:2155	Mutation rewiring degron network	0.3056
p.K2156R	SIDM01159	Other Sarcomas	GDSC	PDTSS	DEG_SPOP_SBC_1	2151:2155	Mutation rewiring degron network	0.3056
p.K2156R	SIDM01077	Prostate Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	2151:2155	Mutation rewiring degron network	0.3056
p.K2156R	SIDM01480	Ovarian Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	2151:2155	Mutation rewiring degron network	0.3056
p.N2292H	SIDM00193	Colorectal Carcinoma	GDSC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1667
p.N2292H	ACH-000991	Colon/Colorectal Cancer	CCLE	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1667
p.N2292H	SNU-81	large intestine	COSMIC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation rewiring degron network	0.1667
p.E1714G	SIDM01045	Endometrial Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.0833
p.E1714G	ACH-000978	Endometrial/Uterine Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.0833
p.E1714G	EN	endometrium	COSMIC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.0833
p.N1610S	SIDM00143	Small Cell Lung Carcinoma	GDSC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.3056
p.N1610S	ACH-000803	Lung Cancer	CCLE	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.3056
p.N1610S	COLO-668	lung	COSMIC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.3056
p.E2286K	SIDM00483	Esophageal Carcinoma	GDSC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation altering degron motif	0.7022
p.E2286K	ACH-001654	Esophageal Cancer	CCLE	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation altering degron motif	0.7022
p.E2286K	SK-GT-4	oesophagus	COSMIC	LNVYKE	LIG_APCC_ABBA_1	2281:2286	Mutation altering degron motif	0.7022
p.G1615D	SIDM00118	Colorectal Carcinoma	GDSC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation altering degron motif	0.7198
p.G1615D	ACH-001081	Colon/Colorectal Cancer	CCLE	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation altering degron motif	0.7198
p.G1615D	HCC2998	large intestine	COSMIC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation altering degron motif	0.7198
p.S1542L	SIDM00118	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation blocking phosphorylation signal	0.7222
p.S1542L	ACH-001081	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation blocking phosphorylation signal	0.7222
p.S1542L	HCC2998	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation blocking phosphorylation signal	0.7222
p.D1695N	SIDM00056	Thyroid Gland Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation rewiring degron network	0.1667
p.S1541L	SIDM01609	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.25
p.S1541L	ACH-000972	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.25
p.S1704N	SIDM01611	Endometrial Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation altering degron motif	0.7069
p.S1704N	ACH-000996	Endometrial/Uterine Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1701:1705	Mutation altering degron motif	0.7069
p.R1558H	ACH-000230	Non-Cancerous	CCLE	ASSSS	DEG_SPOP_SBC_1	1544:1548	Mutation rewiring degron network	0.0556
p.D1606Y	ACH-001113	Lung Cancer	CCLE	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.1944
p.D1606Y	ACH-002156	Lung Cancer	CCLE	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.1944
p.D1606Y	LC-1-sq	lung	COSMIC	SLETGE	DEG_Kelch_Keap1_1	1611:1616	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRWD1

UniProt ID: Q9NSI6

Entrez ID: 54014

Protein name: Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRWD1 in