DegronMD

Uniprot ID: Q9NSI6

Source protein: Bromodomain and WD repeat-containing protein 1

Source gene: BRWD1

Class: DEG_Kelch_Keap1_1

Location: 1611:1616

E3 ligase: KEAP1

DEGRON score: 0.9814

ASA_SCORE: 93.5333

COIL: 0.8048

CONS_SCORE: 0.2658

DSS_SCORE: 0.3573

HELIX: 0.1807

FCONS_SCORE: 0.9731

RIG_SCORE: 0.7765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1610Y	TCGA-3A-A9I9	PAAD	TCGA	SLETGE	DEG_Kelch_Keap1_1	0.3056
p.N1610Y	DO51679	PAAD	ICGC	SLETGE	DEG_Kelch_Keap1_1	0.3056
p.L1618I	TCGA-AA-3977	COAD	TCGA	SLETGE	DEG_Kelch_Keap1_1	0.2778
p.L1618I	DO8730	COAD	ICGC	SLETGE	DEG_Kelch_Keap1_1	0.2778
p.R1626Q	TCGA-B5-A0JY	UCEC	TCGA	SLETGE	DEG_Kelch_Keap1_1	0.0556
p.R1626Q	DO43041	UCEC	ICGC	SLETGE	DEG_Kelch_Keap1_1	0.0556
p.A1622D	DO229037	LICA	ICGC	SLETGE	DEG_Kelch_Keap1_1	0.1667
p.Y1603C	DO44786	LICA	ICGC	SLETGE	DEG_Kelch_Keap1_1	0.1111
p.N1610S	SIDM00143	Small Cell Lung Carcinoma	GDSC	SLETGE	DEG_Kelch_Keap1_1	0.3056
p.N1610S	ACH-000803	Lung Cancer	CCLE	SLETGE	DEG_Kelch_Keap1_1	0.3056
p.N1610S	COLO-668	lung	COSMIC	SLETGE	DEG_Kelch_Keap1_1	0.3056
p.G1615D	SIDM00118	Colorectal Carcinoma	GDSC	SLETGE	DEG_Kelch_Keap1_1	0.7198
p.G1615D	ACH-001081	Colon/Colorectal Cancer	CCLE	SLETGE	DEG_Kelch_Keap1_1	0.7198
p.G1615D	HCC2998	large_intestine	COSMIC	SLETGE	DEG_Kelch_Keap1_1	0.7198
p.D1606Y	ACH-001113	Lung Cancer	CCLE	SLETGE	DEG_Kelch_Keap1_1	0.1944
p.D1606Y	ACH-002156	Lung Cancer	CCLE	SLETGE	DEG_Kelch_Keap1_1	0.1944
p.D1606Y	LC-1-sq	lung	COSMIC	SLETGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_Kelch_Keap1_1	1611:1616	SLETGE	KEAP1	0.9814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons