DegronMD

Uniprot ID: Q9NSI6

Source protein: Bromodomain and WD repeat-containing protein 1

Source gene: BRWD1

Class: LIG_APCC_ABBA_1

Location: 2281:2286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8338

ASA_SCORE: 113.6833

COIL: 0.7813

CONS_SCORE: 0.2244

DSS_SCORE: 0.3571

HELIX: 0.1778

FCONS_SCORE: 0.9842

RIG_SCORE: 0.7745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2294V	TCGA-21-1079	LUSC	TCGA	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.E2294V	DO26846	LUSC	ICGC	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.S2273C	TCGA-60-2698	LUSC	TCGA	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.S2273C	DO26469	LUSC	ICGC	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.S2273Y	TCGA-AG-A002	READ	TCGA	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.S2273Y	TCGA-EO-A22X	UCEC	TCGA	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.S2273Y	DO43907	UCEC	ICGC	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.D2288N	TCGA-BR-4371	STAD	TCGA	LNVYKE	LIG_APCC_ABBA_1	0.2778
p.D2288N	DO38348	STAD	ICGC	LNVYKE	LIG_APCC_ABBA_1	0.2778
p.D2287A	TCGA-BS-A0UJ	UCEC	TCGA	LNVYKE	LIG_APCC_ABBA_1	0.3056
p.D2287A	DO42745	UCEC	ICGC	LNVYKE	LIG_APCC_ABBA_1	0.3056
p.S2293F	TCGA-DK-A1A3	BLCA	TCGA	LNVYKE	LIG_APCC_ABBA_1	0.5833
p.S2293F	DO558	BLCA	ICGC	LNVYKE	LIG_APCC_ABBA_1	0.5833
p.E2294K	TCGA-DK-A6B6	BLCA	TCGA	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.E2294K	DO48576	BLCA	ICGC	LNVYKE	LIG_APCC_ABBA_1	0.1111
p.N2292H	SIDM00193	Colorectal Carcinoma	GDSC	LNVYKE	LIG_APCC_ABBA_1	0.1667
p.N2292H	ACH-000991	Colon/Colorectal Cancer	CCLE	LNVYKE	LIG_APCC_ABBA_1	0.1667
p.N2292H	SNU-81	large_intestine	COSMIC	LNVYKE	LIG_APCC_ABBA_1	0.1667
p.E2286K	SIDM00483	Esophageal Carcinoma	GDSC	LNVYKE	LIG_APCC_ABBA_1	0.7022
p.E2286K	ACH-001654	Esophageal Cancer	CCLE	LNVYKE	LIG_APCC_ABBA_1	0.7022
p.E2286K	SK-GT-4	oesophagus	COSMIC	LNVYKE	LIG_APCC_ABBA_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSI6	Bromodomain and WD repeat-containing protein 1	LIG_APCC_ABBA_1	2281:2286	LNVYKE	APC,CDC20,FZR1	0.8338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons