DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PKTSS
Uniprot ID:
O43303
Source protein:
Centriolar coiled-coil protein of 110 kDa
Source gene:
CCP110
Class:
DEG_SPOP_SBC_1
Location:
188:192
E3 ligase:
SPOP
DEGRON score:
0.6385
ASA_SCORE:
91.52
COIL:
0.8996
CONS_SCORE:
0.3671
DSS_SCORE:
0.5936
HELIX:
0.0478
FCONS_SCORE:
1.034
RIG_SCORE:
0.6412
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CCP110 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43303
Centriolar coiled-coil protein of 110 kDa
DEG_SPOP_SBC_1
188:192
PKTSS
SPOP
0.6385
More...
O43314
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
DEG_SPOP_SBC_1
489:493
PKTSS
SPOP
0.8197
More...
Q14966
Zinc finger protein 638
DEG_SPOP_SBC_1
610:614
PKTSS
SPOP
0.8762
More...
Q6ZT12
E3 ubiquitin-protein ligase UBR3
DEG_SPOP_SBC_1
1063:1067
PKTSS
SPOP
0.955
More...
Q6ZWJ1
Syntaxin-binding protein 4
DEG_SPOP_SBC_1
149:153
PKTSS
SPOP
0.8731
More...
Q8NFC6
Biorientation of chromosomes in cell division protein 1-like 1
DEG_SPOP_SBC_1
2822:2826
PKTSS
SPOP
0.9052
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
3053:3057
PKTSS
SPOP
0.8531
More...
Q96GS4
BLOC-1-related complex subunit 6
DEG_SPOP_SBC_1
62:66
PKTSS
SPOP
0.9347
More...
Q9BX26
Synaptonemal complex protein 2
DEG_SPOP_SBC_1
1141:1145
PKTSS
SPOP
0.958
More...
Q9NSI6
Bromodomain and WD repeat-containing protein 1
DEG_SPOP_SBC_1
1292:1296
PKTSS
SPOP
0.6269
More...
Q9Y6B7
AP-4 complex subunit beta-1
DEG_SPOP_SBC_1
589:593
PKTSS
SPOP
0.9969
More...