DegronMD

Uniprot ID: Q6ZWJ1

Source protein: Syntaxin-binding protein 4

Source gene: STXBP4

Class: DEG_SPOP_SBC_1

Location: 149:153

E3 ligase: SPOP

DEGRON score: 0.8731

ASA_SCORE: 99.04

COIL: 0.9702

CONS_SCORE: 0.4996

DSS_SCORE: 0.5402

HELIX: 0.0116

FCONS_SCORE: 0.9707

RIG_SCORE: 0.6945

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P149Q	TCGA-EE-A2GN	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	0.7035
p.P149Q	DO37896	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	0.7035
p.S141F	DO222749	MELA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.1111
p.P144L	SIDM00915	Small Cell Lung Carcinoma	GDSC	PKTSS	DEG_SPOP_SBC_1	0.1944
p.P144L	ACH-002173	Lung Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	0.1944
p.P144L	NCI-H378	lung	COSMIC	PKTSS	DEG_SPOP_SBC_1	0.1944
p.P143S	SIDM00210	Ovarian Carcinoma	GDSC	PKTSS	DEG_SPOP_SBC_1	0.1667
p.L145M	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.R139C	GP5d	large_intestine	COSMIC	PKTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_SPOP_SBC_1	188:192	PKTSS	SPOP	0.6385	More...
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	489:493	PKTSS	SPOP	0.8197	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	610:614	PKTSS	SPOP	0.8762	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1063:1067	PKTSS	SPOP	0.955	More...
Q6ZWJ1	Syntaxin-binding protein 4	DEG_SPOP_SBC_1	149:153	PKTSS	SPOP	0.8731	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	2822:2826	PKTSS	SPOP	0.9052	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3053:3057	PKTSS	SPOP	0.8531	More...
Q96GS4	BLOC-1-related complex subunit 6	DEG_SPOP_SBC_1	62:66	PKTSS	SPOP	0.9347	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	1141:1145	PKTSS	SPOP	0.958	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1292:1296	PKTSS	SPOP	0.6269	More...
Q9Y6B7	AP-4 complex subunit beta-1	DEG_SPOP_SBC_1	589:593	PKTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons