DegronMD

Uniprot ID: Q9Y6B7

Source protein: AP-4 complex subunit beta-1

Source gene: AP4B1

Class: DEG_SPOP_SBC_1

Location: 589:593

E3 ligase: SPOP

DEGRON score: 0.9969

ASA_SCORE: 84.58

COIL: 0.8178

CONS_SCORE: 0.3552

DSS_SCORE: 0.499

HELIX: 0.156

FCONS_SCORE: 1.0755

RIG_SCORE: 0.7012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A596T	TCGA-KK-A8IG	PRAD	TCGA	PKTSS	DEG_SPOP_SBC_1	0.25
p.A596T	DO219331	PRAD	ICGC	PKTSS	DEG_SPOP_SBC_1	0.25
p.A581S	TCGA-KQ-A41O	BLCA	TCGA	PKTSS	DEG_SPOP_SBC_1	0.1111
p.A581S	DO223589	BLCA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.1111
p.S593F	TCGA-WE-A8K6	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	0.9093
p.S593F	DO51283	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	0.9093
p.G580R	SIDM01187	Breast Carcinoma	GDSC	PKTSS	DEG_SPOP_SBC_1	0.0833
p.G580R	ACH-000568	Breast Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	0.0833
p.G580R	UACC-812	breast	COSMIC	PKTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_SPOP_SBC_1	188:192	PKTSS	SPOP	0.6385	More...
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	489:493	PKTSS	SPOP	0.8197	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	610:614	PKTSS	SPOP	0.8762	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1063:1067	PKTSS	SPOP	0.955	More...
Q6ZWJ1	Syntaxin-binding protein 4	DEG_SPOP_SBC_1	149:153	PKTSS	SPOP	0.8731	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	2822:2826	PKTSS	SPOP	0.9052	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3053:3057	PKTSS	SPOP	0.8531	More...
Q96GS4	BLOC-1-related complex subunit 6	DEG_SPOP_SBC_1	62:66	PKTSS	SPOP	0.9347	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	1141:1145	PKTSS	SPOP	0.958	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1292:1296	PKTSS	SPOP	0.6269	More...
Q9Y6B7	AP-4 complex subunit beta-1	DEG_SPOP_SBC_1	589:593	PKTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons