DegronMD

Uniprot ID: Q9Y2R2

Source protein: Tyrosine-protein phosphatase non-receptor type 22

Source gene: PTPN22

Class: DEG_APCC_KENBOX_2

Location: 465:469

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9549

ASA_SCORE: 100.04

COIL: 0.7498

CONS_SCORE: 0.26

DSS_SCORE: 0.5444

HELIX: 0.162

FCONS_SCORE: 0.9944

RIG_SCORE: 0.7308

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S465I	TCGA-A5-A0G1	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.623
p.S465I	TCGA-AA-A010	COAD	TCGA	SKENF	DEG_APCC_KENBOX_2	0.623
p.S465I	DO42472	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.623
p.S479C	TCGA-AR-A0TX	BRCA	TCGA	SKENF	DEG_APCC_KENBOX_2	0.0556
p.S479C	DO1663	BRCA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.0556
p.E467G	TCGA-BS-A0UF	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.7199
p.E467G	DO41488	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.7199
p.E467G	SIDM00538	Esophageal Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.7199
p.E467G	ACH-001497	Esophageal Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	0.7199
p.E467G	ESO51	oesophagus	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.7199
p.E462D	TCGA-BS-A0UF	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.25
p.E462D	DO41488	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.25
p.Q475E	TCGA-BT-A2LA	BLCA	TCGA	SKENF	DEG_APCC_KENBOX_2	0.1667
p.Q475E	TCGA-GV-A3QI	BLCA	TCGA	SKENF	DEG_APCC_KENBOX_2	0.1667
p.Q475E	DO470	BLCA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.1667
p.Q475E	DO561	BLCA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.1667
p.E467K	TCGA-D3-A2JH	SKCM	TCGA	SKENF	DEG_APCC_KENBOX_2	0.7022
p.E467K	DO47263	SKCM	ICGC	SKENF	DEG_APCC_KENBOX_2	0.7022
p.E467K	SIDM00545	Melanoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.7022
p.E467K	ACH-000987	Skin Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	0.7022
p.E467K	Mewo	skin	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.7022
p.S479Y	TCGA-FI-A2D5	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.0556
p.S479Y	DO41331	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.0556
p.F469C	TCGA-FI-A2D5	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.5996
p.F469C	DO41331	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.5996
p.Q456E	SIDM01087	Melanoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.0833
p.Q456E	SIDM01118	Small Cell Lung Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.0833
p.Q456E	SIDM00511	Small Cell Lung Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.0833
p.Q456E	SIDM00628	Breast Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.0833
p.F469L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.587
p.F469L	ACH-000824	Esophageal Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	0.587
p.F469L	KYSE-510	oesophagus	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.587
p.R458T	SIDM00603	Head and Neck Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.1389
p.R458T	ACH-001543	Head and Neck Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	0.1389
p.R458T	KOSC-2	upper_aerodigestive_tract	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.1389
p.N479T	MCC13	skin	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.0556
p.Y479C	HCC-78	lung	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.0556
p.Y479C	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.0556
p.V458A	SN12C	kidney	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.1389
p.S456Y	SNU-81	large_intestine	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.0833
p.S469Y	LNCaP-Clone-FGC	prostate	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.712
p.E478K	TMK-1	stomach	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75330	Hyaluronan mediated motility receptor	DEG_APCC_KENBOX_2	695:699	SKENF	APC,CDC20,FZR1	0.9622	More...
O95425	Supervillin	DEG_APCC_KENBOX_2	1414:1418	SKENF	APC,CDC20,FZR1	0.9572	More...
Q8NCD3	Holliday junction recognition protein	DEG_APCC_KENBOX_2	320:324	SKENF	APC,CDC20,FZR1	0.9053	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_APCC_KENBOX_2	465:469	SKENF	APC,CDC20,FZR1	0.9549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENF

Degron related mutations and impact score

Drug responses associated with PTPN22 mutations

All proteins holding degron of SKENF