DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
SKENF
Uniprot ID:
O95425
Source protein:
Supervillin
Source gene:
SVIL
Class:
DEG_APCC_KENBOX_2
Location:
1414:1418
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9572
ASA_SCORE:
77.82
COIL:
0.6984
CONS_SCORE:
0.5995
DSS_SCORE:
0.234
HELIX:
0.2254
FCONS_SCORE:
1.0188
RIG_SCORE:
0.7321
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1414T
SIDM00203
Ewing's Sarcoma
GDSC
SKENF
DEG_APCC_KENBOX_2
0.6005
p.S1414T
SIDM00052
Esophageal Squamous Cell Carcinoma
GDSC
SKENF
DEG_APCC_KENBOX_2
0.6005
p.S1405L
DO233193
GACA
ICGC
SKENF
DEG_APCC_KENBOX_2
0.5278
p.A1410V
TCGA-CG-4465
STAD
TCGA
SKENF
DEG_APCC_KENBOX_2
0.2222
p.A1410V
DO38627
STAD
ICGC
SKENF
DEG_APCC_KENBOX_2
0.2222
p.L1423M
TCGA-MP-A4TD
LUAD
TCGA
SKENF
DEG_APCC_KENBOX_2
0.1944
p.L1423M
DO45363
LUAD
ICGC
SKENF
DEG_APCC_KENBOX_2
0.1944
p.K1409N
HCC-78
lung
COSMIC
SKENF
DEG_APCC_KENBOX_2
0.1944
p.T1408N
TCGA-D1-A2G5
UCEC
TCGA
SKENF
DEG_APCC_KENBOX_2
0.1667
p.T1408N
DO40918
UCEC
ICGC
SKENF
DEG_APCC_KENBOX_2
0.1667
p.R1424L
TCGA-JV-A75J
SARC
TCGA
SKENF
DEG_APCC_KENBOX_2
0.1667
p.R1424L
DO220183
SARC
ICGC
SKENF
DEG_APCC_KENBOX_2
0.1667
p.E1406D
DO234413
ESAD
ICGC
SKENF
DEG_APCC_KENBOX_2
0.1111
p.A1404V
HCT-116
large_intestine
COSMIC
SKENF
DEG_APCC_KENBOX_2
0.0556
Showing 1 to 14 of 14 entries
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Drug responses associated with SVIL mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of SKENF
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NCD3
Holliday junction recognition protein
DEG_APCC_KENBOX_2
320:324
SKENF
APC,CDC20,FZR1
0.9053
More...
O75330
Hyaluronan mediated motility receptor
DEG_APCC_KENBOX_2
695:699
SKENF
APC,CDC20,FZR1
0.9622
More...
O95425
Supervillin
DEG_APCC_KENBOX_2
1414:1418
SKENF
APC,CDC20,FZR1
0.9572
More...
Q9Y2R2
Tyrosine-protein phosphatase non-receptor type 22
DEG_APCC_KENBOX_2
465:469
SKENF
APC,CDC20,FZR1
0.9549
More...
Showing 1 to 4 of 4 entries
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