DegronMD

Uniprot ID: O95425

Source protein: Supervillin

Source gene: SVIL

Class: DEG_APCC_KENBOX_2

Location: 1414:1418

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9572

ASA_SCORE: 77.82

COIL: 0.6984

CONS_SCORE: 0.5995

DSS_SCORE: 0.234

HELIX: 0.2254

FCONS_SCORE: 1.0188

RIG_SCORE: 0.7321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1410V	TCGA-CG-4465	STAD	TCGA	SKENF	DEG_APCC_KENBOX_2	0.2222
p.A1410V	DO38627	STAD	ICGC	SKENF	DEG_APCC_KENBOX_2	0.2222
p.T1408N	TCGA-D1-A2G5	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.1667
p.T1408N	DO40918	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.1667
p.R1424L	TCGA-JV-A75J	SARC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.1667
p.R1424L	DO220183	SARC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.1667
p.L1423M	TCGA-MP-A4TD	LUAD	TCGA	SKENF	DEG_APCC_KENBOX_2	0.1944
p.L1423M	DO45363	LUAD	ICGC	SKENF	DEG_APCC_KENBOX_2	0.1944
p.E1406D	DO234413	ESAD	ICGC	SKENF	DEG_APCC_KENBOX_2	0.1111
p.S1405L	DO233193	GACA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.5278
p.S1414T	SIDM00203	Ewing's Sarcoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.6005
p.S1414T	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.6005
p.A1404V	HCT-116	large_intestine	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.0556
p.K1409N	HCC-78	lung	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75330	Hyaluronan mediated motility receptor	DEG_APCC_KENBOX_2	695:699	SKENF	APC,CDC20,FZR1	0.9622	More...
O95425	Supervillin	DEG_APCC_KENBOX_2	1414:1418	SKENF	APC,CDC20,FZR1	0.9572	More...
Q8NCD3	Holliday junction recognition protein	DEG_APCC_KENBOX_2	320:324	SKENF	APC,CDC20,FZR1	0.9053	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_APCC_KENBOX_2	465:469	SKENF	APC,CDC20,FZR1	0.9549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons