DegronMD - O95425(SVIL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1112L	TCGA-2W-A8YY	CESC	TCGA	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.7582
p.P1112L	TCGA-CA-5256	COAD	TCGA	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.7582
p.P1112L	DO223732	CESC	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.7582
p.P1112L	DO10526	COAD	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.7582
p.R244W	TCGA-2W-A8YY	CESC	TCGA	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1944
p.R244W	DO223732	CESC	ICGC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1944
p.T1111M	TCGA-34-2600	LUSC	TCGA	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.8534
p.T1111M	TCGA-A5-A0G1	UCEC	TCGA	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.8534
p.T1111M	DO27081	LUSC	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.8534
p.T1111M	DO42472	UCEC	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.8534
p.E798K	TCGA-3C-AALI	BRCA	TCGA	PDSST	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.0556
p.E798K	DO219589	BRCA	ICGC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.0556
p.I1236S	TCGA-99-8025	LUAD	TCGA	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation rewiring degron network	0.2778
p.P808H	TCGA-A5-A0G2	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.7694
p.P808H	DO41235	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.7694
p.S228L	TCGA-AJ-A3EL	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7667
p.S228L	TCGA-BH-A0BP	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7667
p.S228L	DO4056	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7667
p.S228L	DO41542	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7667
p.S228L	ACH-001850	Gallbladder Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7667
p.E817K	TCGA-AX-A05Z	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1944
p.E817K	DO40884	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1944
p.A249T	TCGA-AX-A2HD	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7139
p.A249T	DO42608	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7139
p.P1121A	TCGA-BQ-7046	KIRP	TCGA	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.1667
p.P1121A	DO20885	KIRP	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.1667
p.A1410V	TCGA-CG-4465	STAD	TCGA	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.2222
p.A1410V	DO38627	STAD	ICGC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.2222
p.I1229T	TCGA-CM-6674	COAD	TCGA	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation altering degron motif	0.7078
p.I1229T	DO10092	COAD	ICGC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation altering degron motif	0.7078
p.T1408N	TCGA-D1-A2G5	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.1667
p.T1408N	DO40918	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.1667
p.S1120L	TCGA-DK-A1AC	BLCA	TCGA	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation blocking phosphorylation signal	0.6389
p.S1120L	DO514	BLCA	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation blocking phosphorylation signal	0.6389
p.L1118P	TCGA-DU-6392	LGG	TCGA	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.25
p.L1118P	DO22237	LGG	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.25
p.R244L	TCGA-GN-A26D	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1944
p.R244L	DO37480	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1944
p.R1424L	TCGA-JV-A75J	SARC	TCGA	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.1667
p.R1424L	DO220183	SARC	ICGC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.1667
p.L1423M	TCGA-MP-A4TD	LUAD	TCGA	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.1944
p.L1423M	DO45363	LUAD	ICGC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.1944
p.S810F	TCGA-XF-AAML	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.7982
p.S810F	DO51933	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.7982
p.R215Q	DO224885	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.R215Q	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.R215Q	ACH-001738	Leukemia	CCLE	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.R215Q	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.D243N	DO10859	ESAD	ICGC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.E1406D	DO234413	ESAD	ICGC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.1111
p.G1107V	DO223083	ESCA	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.2778
p.S1405L	DO233193	GACA	ICGC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation blocking phosphorylation signal	0.5278
p.E225K	DO233882	GACA	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.591
p.A803V	DO229346	LAML	ICGC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1944
p.S226I	DO228934	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7341
p.Q216K	DO228974	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.1111
p.S1122R	DO229028	LICA	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation blocking phosphorylation signal	0.5833
p.S811Y	DO229026	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.712
p.V1219L	DO229047	LICA	ICGC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation rewiring degron network	0.0556
p.P1231L	DO229052	LICA	ICGC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation altering degron motif	0.7582
p.G1238V	DO229009	LICA	ICGC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation rewiring degron network	0.2222
p.M1125I	DO52677	MALY	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.0556
p.E225G	DO228851	MALY	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.6087
p.R260Q	DO35442	PACA	ICGC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.A1228V	DO232224	PBCA	ICGC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation rewiring degron network	0.3056
p.F222S	DO36531	READ	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2778
p.M240I	DO37442	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation blocking phosphorylation signal	0.5278
p.E1115D	DO38404	STAD	ICGC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.6758
p.R235I	DO41020	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.1389
p.F225V	DO43041	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7068
p.V259M	DO43298	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation blocking phosphorylation signal	0.6111
p.R215W	SIDM02041	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.R215W	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.R215W	SIDM00808	Burkitt's Lymphoma	GDSC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.R215W	SIDM01254	Burkitt's Lymphoma	GDSC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0833
p.M1103L	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.1667
p.M1103L	ACH-000365	Lymphoma	CCLE	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.1667
p.M1103L	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.1667
p.S1414T	SIDM00203	Ewing's Sarcoma	GDSC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation altering degron motif	0.6005
p.S1414T	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation altering degron motif	0.6005
p.S251G	SIDM00537	Colorectal Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6993
p.S251G	ACH-001345	Colon/Colorectal Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6993
p.S251G	GP5d	large intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6993
p.L220M	SIDM01608	Endometrial Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2222
p.L220M	ACH-000990	Endometrial/Uterine Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2222
p.L819F	ACH-000629	Brain Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1389
p.S259F	ACH-000635	Ovarian Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	249:253	Mutation blocking phosphorylation signal	0.6111
p.R1111K	SNU-81	large intestine	COSMIC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation altering degron motif	0.7237
p.Q1118P	CAL-148	breast	COSMIC	IKTPTGE	DEG_SCF_FBW7_2	1109:1115	Mutation rewiring degron network	0.25
p.S1231W	HCC2218	breast	COSMIC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation altering degron motif	0.7874
p.S1231W	AGS	stomach	COSMIC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation altering degron motif	0.7874
p.M1227I	HCT-15	large intestine	COSMIC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation blocking phosphorylation signal	0.7222
p.R806T	ChaGo-K-1	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.2778
p.F1237L	C-33-A	cervix	COSMIC	ITPVAS	DEG_SCF_FBW7_1	1229:1234	Mutation rewiring degron network	0.25
p.R804Q	NCI-H647	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.2222
p.A1404V	HCT-116	large intestine	COSMIC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.0556
p.R812K	TASK1	bone	COSMIC	PDSST	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.7237
p.K1409N	HCC-78	lung	COSMIC	SKENF	DEG_APCC_KENBOX_2	1414:1418	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SVIL

UniProt ID: O95425

Entrez ID: 6840

Protein name: Supervillin (Archvillin) (p205/p250)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SVIL in