DegronMD

Uniprot ID: O95425

Source protein: Supervillin

Source gene: SVIL

Class: DEG_SCF_FBW7_1

Location: 1229:1234

E3 ligase: FBXW7

DEGRON score: 0.9922

ASA_SCORE: 82.0333

COIL: 0.9315

CONS_SCORE: 0.4091

DSS_SCORE: 0.4499

HELIX: 0.0167

FCONS_SCORE: 0.9504

RIG_SCORE: 0.7641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1236S	TCGA-99-8025	LUAD	TCGA	ITPVAS	DEG_SCF_FBW7_1	0.2778
p.I1229T	TCGA-CM-6674	COAD	TCGA	ITPVAS	DEG_SCF_FBW7_1	0.7078
p.I1229T	DO10092	COAD	ICGC	ITPVAS	DEG_SCF_FBW7_1	0.7078
p.V1219L	DO229047	LICA	ICGC	ITPVAS	DEG_SCF_FBW7_1	0.0556
p.P1231L	DO229052	LICA	ICGC	ITPVAS	DEG_SCF_FBW7_1	0.7582
p.G1238V	DO229009	LICA	ICGC	ITPVAS	DEG_SCF_FBW7_1	0.2222
p.A1228V	DO232224	PBCA	ICGC	ITPVAS	DEG_SCF_FBW7_1	0.3056
p.S1231W	HCC2218	breast	COSMIC	ITPVAS	DEG_SCF_FBW7_1	0.7874
p.S1231W	AGS	stomach	COSMIC	ITPVAS	DEG_SCF_FBW7_1	0.7874
p.M1227I	HCT-15	large_intestine	COSMIC	ITPVAS	DEG_SCF_FBW7_1	0.7222
p.F1237L	C-33-A	cervix	COSMIC	ITPVAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95425	Supervillin	DEG_SCF_FBW7_1	1229:1234	ITPVAS	FBXW7	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons