DegronMD

Uniprot ID: O95425

Source protein: Supervillin

Source gene: SVIL

Class: DEG_SPOP_SBC_1

Location: 249:253

E3 ligase: SPOP

DEGRON score: 0.9277

ASA_SCORE: 74.36

COIL: 0.746

CONS_SCORE: 0.3968

DSS_SCORE: 0.7252

HELIX: 0.2262

FCONS_SCORE: 0.9718

RIG_SCORE: 0.5968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R244W	TCGA-2W-A8YY	CESC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1944
p.R244W	DO223732	CESC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1944
p.A249T	TCGA-AX-A2HD	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7139
p.A249T	DO42608	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7139
p.R244L	TCGA-GN-A26D	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1944
p.R244L	DO37480	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1944
p.D243N	DO10859	ESAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1667
p.R260Q	DO35442	PACA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1389
p.M240I	DO37442	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.5278
p.V259M	DO43298	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.6111
p.S251G	SIDM00537	Colorectal Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.6993
p.S251G	ACH-001345	Colon/Colorectal Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.6993
p.S251G	GP5d	large_intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.6993
p.S259F	ACH-000635	Ovarian Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons