DegronMD

Uniprot ID: Q8WYN3

Source protein: Cysteine/serine-rich nuclear protein 3

Source gene: CSRNP3

Class: DEG_SPOP_SBC_1

Location: 297:301

E3 ligase: SPOP

DEGRON score: 0.8601

ASA_SCORE: 81.96

COIL: 0.8516

CONS_SCORE: 0.3329

DSS_SCORE: 0.4623

HELIX: 0.1278

FCONS_SCORE: 0.8294

RIG_SCORE: 0.6038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H298Q	TCGA-15-1446	GBM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.647
p.H298Q	DO12490	GBM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.647
p.A306T	TCGA-2W-A8YY	CESC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1944
p.A306T	DO223732	CESC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1944
p.P304H	TCGA-77-7335	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.25
p.P304H	TCGA-A5-A0G1	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.25
p.P304H	DO26707	LUSC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.25
p.P304H	DO42472	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.25
p.P304H	SIDM00721	Small Cell Lung Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.25
p.P304H	NCI-H250	lung	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.25
p.V309I	TCGA-AD-5900	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1111
p.V309I	TCGA-BR-6706	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1111
p.V309I	DO8514	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1111
p.V309I	DO38211	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1111
p.S301F	TCGA-BR-8680	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7982
p.S301F	DO47769	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7982
p.L288M	TCGA-IB-7651	PAAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.0833
p.L288M	DO46657	PAAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.C291R	TCGA-WS-AB45	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1667
p.C291R	DO51734	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1667
p.A297S	DO228948	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7588
p.T287M	SIDM00217	Colorectal Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.0556
p.T287M	SNU-1040	large_intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.0556
p.R295H	ACH-000261	Lung Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.2778
p.R295H	ACH-002122	Lung Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.2778
p.H302Q	ACH-001561	Lung Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons