DegronMD

Uniprot ID: Q9ULI4

Source protein: Kinesin-like protein KIF26A

Source gene: KIF26A

Class: DEG_SPOP_SBC_1

Location: 1445:1449

E3 ligase: SPOP

DEGRON score: 0.9988

ASA_SCORE: 67.48

COIL: 0.7458

CONS_SCORE: 0.3665

DSS_SCORE: 0.6363

HELIX: 0.1604

FCONS_SCORE: 1.095

RIG_SCORE: 0.5878

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1447I	TCGA-DU-6392	LGG	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7341
p.S1447I	DO22237	LGG	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7341
p.E1442K	TCGA-FR-A726	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.25
p.E1442K	DO48665	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.25
p.P1459T	TCGA-MP-A4TK	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.0556
p.P1459T	DO45384	LUAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0556
p.S1447N	DO233885	GACA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7069
p.A1436S	DO228985	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.P1459S	DO229462	SKCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0556
p.P1458L	DO218898	SKCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.R1452P	DO229151	THCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.25
p.A1445V	SIDM00335	Endometrial Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.5825
p.A1445V	SIDM00217	Colorectal Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.5825
p.A1445V	SNU-1040	large_intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.5825
p.A1445V	MFE-280	endometrium	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.5825
p.S1437F	SIDM01077	Prostate Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.5556
p.S1437F	ACH-000115	Prostate Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.5556
p.S1437F	VCaP	prostate	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.5556
p.A1436P	SIDM01105	Melanoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.A1436P	ACH-000423	Skin Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.0833
p.A1436P	SK-MEL-3	skin	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.S1448I	SIDM01318	Hepatocellular Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.7341
p.S1448I	ACH-001318	Liver Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.7341
p.S1448N	SIDM01617	Endometrial Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.7069
p.S1448N	ACH-000994	Endometrial/Uterine Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons