DegronMD

Uniprot ID: Q05952

Source protein: Nuclear transition protein 2

Source gene: TNP2

Class: DEG_SPOP_SBC_1

Location: 62:66

E3 ligase: SPOP

DEGRON score: 0.9869

ASA_SCORE: 85.44

COIL: 0.9224

CONS_SCORE: 0.8916

DSS_SCORE: 0.925

HELIX: 0.0344

FCONS_SCORE: 1.3047

RIG_SCORE: 0.4081

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R57C	TCGA-A5-A0G1	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1944
p.R57C	DO42472	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1944
p.P53L	TCGA-AX-A1C5	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.0833
p.P53L	DO227752	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.P53L	DO41422	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.N58I	TCGA-CD-5801	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2222
p.N58I	DO38563	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2222
p.S65L	TCGA-EE-A2MM	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7667
p.S65L	DO222678	MELA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7667
p.S65L	DO229459	SKCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7667
p.S65L	DO37770	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7667
p.T60A	TCGA-QG-A5Z1	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2778
p.T60A	DO51731	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.T60A	SIDM01878	Non-Cancerous	GDSC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.T60A	SIDM00053	Pancreatic Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.T60A	ACH-002360	Non-Cancerous	CCLE	AHSSS	DEG_SPOP_SBC_1	0.2778
p.P73T	DO223457	CLLE	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1389
p.S55R	DO228971	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1389
p.A54D	DO229029	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1111
p.H68N	DO229026	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.S64R	DO229041	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7427
p.R57H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	AHSSS	DEG_SPOP_SBC_1	0.1944
p.R57H	ACH-000960	Leukemia	CCLE	AHSSS	DEG_SPOP_SBC_1	0.1944
p.R57H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.1944
p.G67S	SIDM01763	Rhabdomyosarcoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.3056
p.G67S	ACH-000079	Non-Cancerous	CCLE	AHSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons