DegronMD

Uniprot ID: O15015

Source protein: Zinc finger protein 646

Source gene: ZNF646

Class: DEG_SPOP_SBC_1

Location: 903:907

E3 ligase: SPOP

DEGRON score: 0.9691

ASA_SCORE: 60.96

COIL: 0.7342

CONS_SCORE: 0.5858

DSS_SCORE: 0.5915

HELIX: 0.0738

FCONS_SCORE: 0.9947

RIG_SCORE: 0.5952

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A903T	TCGA-2W-A8YY	CESC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7139
p.A903T	DO223732	CESC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7139
p.S907C	TCGA-AC-A23H	BRCA	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7541
p.S907C	DO2401	BRCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7541
p.R893W	TCGA-AX-A1CE	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.0556
p.R893W	DO42280	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0556
p.R901H	TCGA-KN-8428	KICH	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2778
p.R901H	DO220484	KICH	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.M909T	TCGA-MN-A4N4	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2778
p.M909T	DO26250	LUAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.H899R	TCGA-QG-A5Z2	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2222
p.H899R	DO44096	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2222
p.S906T	SIDM00934	Pancreatic Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.6005
p.S906T	SIDM00342	T-Lymphoblastic Leukemia	GDSC	AHSSS	DEG_SPOP_SBC_1	0.6005
p.S906Y	SIDM00934	Pancreatic Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.712
p.S906Y	SIDM00342	T-Lymphoblastic Leukemia	GDSC	AHSSS	DEG_SPOP_SBC_1	0.712
p.S906Y	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.712
p.S906Y	CAPAN-1	pancreas	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.712
p.S906F	ACH-000247	Gastric Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.7982
p.S906F	ACH-000984	Endometrial/Uterine Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.7982
p.S906F	ACH-002197	Lung Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.7982
p.S906F	ACH-002244	Head and Neck Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.7982
p.S906F	HO-1-N-1	salivary_gland	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.7982
p.S906F	OCUM-1	stomach	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.7982
p.S906F	SBC-3	lung	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons