DegronMD - O60269(GPRIN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E219K	TCGA-22-5491	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0833
p.E219K	DO26420	LUSC	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0833
p.L368V	TCGA-33-4586	LUSC	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.2778
p.L368V	TCGA-33-4586	LUSC	TCGA	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.25
p.L368V	DO27318	LUSC	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.2778
p.L368V	DO27318	LUSC	ICGC	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.25
p.E374D	TCGA-86-8672	LUAD	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.5647
p.E374D	DO25434	LUAD	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.5647
p.R445W	TCGA-A5-A1OF	UCEC	TCGA	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2222
p.R445W	TCGA-DX-A8BZ	SARC	TCGA	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2222
p.R445W	DO233732	GACA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2222
p.R445W	DO220070	SARC	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2222
p.R445W	DO42568	UCEC	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2222
p.V382M	TCGA-AJ-A23O	UCEC	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.2222
p.V382M	DO43290	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.2222
p.Q220H	TCGA-AP-A059	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0556
p.Q220H	DO41361	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0556
p.P357H	TCGA-AP-A059	UCEC	TCGA	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.25
p.P357H	DO41361	UCEC	ICGC	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.25
p.V430E	TCGA-AP-A1DO	UCEC	TCGA	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.25
p.V430E	DO43250	UCEC	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.25
p.P376L	TCGA-AX-A1C5	UCEC	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7582
p.P376L	TCGA-B5-A11E	UCEC	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7582
p.P376L	DO233888	GACA	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7582
p.P376L	DO41644	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7582
p.P376L	DO41422	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7582
p.A206T	TCGA-AX-A2HC	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7139
p.A206T	DO41572	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7139
p.K216R	TCGA-B5-A3FC	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation substituting flanking lysine	0.2778
p.K216R	DO41871	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation substituting flanking lysine	0.2778
p.H361Q	TCGA-BF-A1PV	SKCM	TCGA	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation altering degron motif	0.647
p.H361Q	DO47309	SKCM	ICGC	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation altering degron motif	0.647
p.V362L	TCGA-BF-A1PV	SKCM	TCGA	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation altering degron motif	0.5654
p.V362L	DO47309	SKCM	ICGC	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation altering degron motif	0.5654
p.R380W	TCGA-BR-4363	STAD	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.2778
p.R380W	DO38815	STAD	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.2778
p.R380W	DO42673	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.2778
p.E373G	TCGA-CX-A4AQ	HNSC	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.6087
p.E373G	DO223265	HNSC	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.6087
p.D385N	TCGA-D3-A5GR	SKCM	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.1389
p.D385N	TCGA-DF-A2KU	UCEC	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.1389
p.D385N	DO47436	SKCM	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.1389
p.D385N	DO223286	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.1389
p.G202V	TCGA-D9-A1X3	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202V	DO37456	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.E374K	TCGA-DU-6407	LGG	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.591
p.E374K	DO22295	LGG	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.591
p.S429F	TCGA-EE-A2MQ	SKCM	TCGA	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation blocking phosphorylation signal	0.6667
p.S429F	DO220890	MELA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation blocking phosphorylation signal	0.6667
p.S429F	DO37810	SKCM	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation blocking phosphorylation signal	0.6667
p.E214K	TCGA-K4-A6FZ	BLCA	TCGA	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.E214K	DO44045	BLCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.P197T	TCGA-KS-A41F	THCA	TCGA	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0833
p.P197T	DO40423	THCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0833
p.S371I	TCGA-XC-AA0X	LUSC	TCGA	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7341
p.S371I	DO52026	LUSC	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7341
p.S371I	SIDM00500	Colorectal Carcinoma	GDSC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7341
p.S371I	ACH-000959	Colon/Colorectal Cancer	CCLE	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.7341
p.E365Q	DO48429	BLCA	ICGC	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation altering degron motif	0.6744
p.G202W	DO224796	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202W	DO222485	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202W	DO229010	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202W	DO229013	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202W	DO229016	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202W	DO229003	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202W	DO229005	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202W	DO51017	LAML	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.G202W	DO229213	THCA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.V375A	DO229010	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.6936
p.V375A	DO229013	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.6936
p.V375A	DO229016	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.6936
p.V375A	DO229003	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.6936
p.V375A	DO229005	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation altering degron motif	0.6936
p.R446H	DO229003	COCA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.R446H	DO49670	LIAD	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.R380Q	DO234285	ESAD	ICGC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.2778
p.R433Q	DO233766	GACA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.6218
p.P352L	DO233885	GACA	ICGC	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1111
p.R438Q	DO11854	GBM	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.6218
p.L201M	DO229028	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1944
p.T204S	DO26719	LUSC	ICGC	AHSSS	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2778
p.D426N	DO220851	MELA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1389
p.R446C	SIDM01090	Colorectal Carcinoma	GDSC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.R446C	SIDM00785	Acute Myeloid Leukemia	GDSC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.R446C	SIDM00628	Breast Carcinoma	GDSC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.R446C	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.A386V	SIDM01183	Other Solid Cancers	GDSC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.1111
p.A386V	ACH-001417	Lung Cancer	CCLE	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.1111
p.A386V	UMC-11	lung	COSMIC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.1111
p.A356V	SIDM00761	Small Cell Lung Carcinoma	GDSC	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.2222
p.V379M	SIDM01185	Other Solid Cancers	GDSC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.3056
p.V379M	ACH-002204	Bone Cancer	CCLE	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.3056
p.V379M	U-CH2	bone	COSMIC	SSLEEVPSP	DEG_COP1_1	370:378	Mutation rewiring degron network	0.3056
p.L428V	ACH-000055	Brain Cancer	CCLE	RRGPLRAVM	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1944
p.P352S	ACH-000865	Esophageal Cancer	CCLE	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1111
p.P352S	ACH-002147	Skin Cancer	CCLE	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1111
p.P352S	K2	skin	COSMIC	LHVFPE	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPRIN2

UniProt ID: O60269

Entrez ID: 9721

Protein name: G protein-regulated inducer of neurite outgrowth 2 (GRIN2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPRIN2 in