DegronMD

Uniprot ID: O60269

Source protein: G protein-regulated inducer of neurite outgrowth 2

Source gene: GPRIN2

Class: DEG_APCC_DBOX_1

Location: 433:441

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9241

ASA_SCORE: 76.6556

COIL: 0.3659

CONS_SCORE: 0.6501

DSS_SCORE: 0.4739

HELIX: 0.5926

FCONS_SCORE: 1.0924

RIG_SCORE: 0.7053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R445W	TCGA-A5-A1OF	UCEC	TCGA	RRGPLRAVM	DEG_APCC_DBOX_1	0.2222
p.R445W	TCGA-DX-A8BZ	SARC	TCGA	RRGPLRAVM	DEG_APCC_DBOX_1	0.2222
p.R445W	DO233732	GACA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.2222
p.R445W	DO220070	SARC	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.2222
p.R445W	DO42568	UCEC	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.2222
p.V430E	TCGA-AP-A1DO	UCEC	TCGA	RRGPLRAVM	DEG_APCC_DBOX_1	0.25
p.V430E	DO43250	UCEC	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.25
p.S429F	TCGA-EE-A2MQ	SKCM	TCGA	RRGPLRAVM	DEG_APCC_DBOX_1	0.6667
p.S429F	DO220890	MELA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.6667
p.S429F	DO37810	SKCM	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.6667
p.R446H	DO229003	COCA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.1944
p.R446H	DO49670	LIAD	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.1944
p.R433Q	DO233766	GACA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.6218
p.R438Q	DO11854	GBM	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.6218
p.D426N	DO220851	MELA	ICGC	RRGPLRAVM	DEG_APCC_DBOX_1	0.1389
p.R446C	SIDM01090	Colorectal Carcinoma	GDSC	RRGPLRAVM	DEG_APCC_DBOX_1	0.1944
p.R446C	SIDM00785	Acute Myeloid Leukemia	GDSC	RRGPLRAVM	DEG_APCC_DBOX_1	0.1944
p.R446C	SIDM00628	Breast Carcinoma	GDSC	RRGPLRAVM	DEG_APCC_DBOX_1	0.1944
p.R446C	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	RRGPLRAVM	DEG_APCC_DBOX_1	0.1944
p.L428V	ACH-000055	Brain Cancer	CCLE	RRGPLRAVM	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_APCC_DBOX_1	433:441	RRGPLRAVM	APC,CDC20,FZR1	0.9241	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons