DegronMD

Uniprot ID: O60269

Source protein: G protein-regulated inducer of neurite outgrowth 2

Source gene: GPRIN2

Class: LIG_APCC_ABBA_1

Location: 360:365

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7761

ASA_SCORE: 86.95

COIL: 0.67

CONS_SCORE: 0.7012

DSS_SCORE: 0.2833

HELIX: 0.2605

FCONS_SCORE: 1.2199

RIG_SCORE: 0.8122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L368V	TCGA-33-4586	LUSC	TCGA	LHVFPE	LIG_APCC_ABBA_1	0.25
p.L368V	DO27318	LUSC	ICGC	LHVFPE	LIG_APCC_ABBA_1	0.25
p.P357H	TCGA-AP-A059	UCEC	TCGA	LHVFPE	LIG_APCC_ABBA_1	0.25
p.P357H	DO41361	UCEC	ICGC	LHVFPE	LIG_APCC_ABBA_1	0.25
p.H361Q	TCGA-BF-A1PV	SKCM	TCGA	LHVFPE	LIG_APCC_ABBA_1	0.647
p.H361Q	DO47309	SKCM	ICGC	LHVFPE	LIG_APCC_ABBA_1	0.647
p.V362L	TCGA-BF-A1PV	SKCM	TCGA	LHVFPE	LIG_APCC_ABBA_1	0.5654
p.V362L	DO47309	SKCM	ICGC	LHVFPE	LIG_APCC_ABBA_1	0.5654
p.E365Q	DO48429	BLCA	ICGC	LHVFPE	LIG_APCC_ABBA_1	0.6744
p.P352L	DO233885	GACA	ICGC	LHVFPE	LIG_APCC_ABBA_1	0.1111
p.A356V	SIDM00761	Small Cell Lung Carcinoma	GDSC	LHVFPE	LIG_APCC_ABBA_1	0.2222
p.P352S	ACH-000865	Esophageal Cancer	CCLE	LHVFPE	LIG_APCC_ABBA_1	0.1111
p.P352S	ACH-002147	Skin Cancer	CCLE	LHVFPE	LIG_APCC_ABBA_1	0.1111
p.P352S	K2	skin	COSMIC	LHVFPE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60269	G protein-regulated inducer of neurite outgrowth 2	LIG_APCC_ABBA_1	360:365	LHVFPE	APC,CDC20,FZR1	0.7761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons