DegronMD

Uniprot ID: O60269

Source protein: G protein-regulated inducer of neurite outgrowth 2

Source gene: GPRIN2

Class: DEG_COP1_1

Location: 370:378

E3 ligase: COP1

DEGRON score: 0.5751

ASA_SCORE: 91.7778

COIL: 0.891

CONS_SCORE: 0.5212

DSS_SCORE: 0.3249

HELIX: 0.0509

FCONS_SCORE: 0.7007

RIG_SCORE: 0.7362

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L368V	TCGA-33-4586	LUSC	TCGA	SSLEEVPSP	DEG_COP1_1	0.2778
p.L368V	DO27318	LUSC	ICGC	SSLEEVPSP	DEG_COP1_1	0.2778
p.E374D	TCGA-86-8672	LUAD	TCGA	SSLEEVPSP	DEG_COP1_1	0.5647
p.E374D	DO25434	LUAD	ICGC	SSLEEVPSP	DEG_COP1_1	0.5647
p.V382M	TCGA-AJ-A23O	UCEC	TCGA	SSLEEVPSP	DEG_COP1_1	0.2222
p.V382M	DO43290	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	0.2222
p.P376L	TCGA-AX-A1C5	UCEC	TCGA	SSLEEVPSP	DEG_COP1_1	0.7582
p.P376L	TCGA-B5-A11E	UCEC	TCGA	SSLEEVPSP	DEG_COP1_1	0.7582
p.P376L	DO233888	GACA	ICGC	SSLEEVPSP	DEG_COP1_1	0.7582
p.P376L	DO41644	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	0.7582
p.P376L	DO41422	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	0.7582
p.R380W	TCGA-BR-4363	STAD	TCGA	SSLEEVPSP	DEG_COP1_1	0.2778
p.R380W	DO38815	STAD	ICGC	SSLEEVPSP	DEG_COP1_1	0.2778
p.R380W	DO42673	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	0.2778
p.E373G	TCGA-CX-A4AQ	HNSC	TCGA	SSLEEVPSP	DEG_COP1_1	0.6087
p.E373G	DO223265	HNSC	ICGC	SSLEEVPSP	DEG_COP1_1	0.6087
p.D385N	TCGA-D3-A5GR	SKCM	TCGA	SSLEEVPSP	DEG_COP1_1	0.1389
p.D385N	TCGA-DF-A2KU	UCEC	TCGA	SSLEEVPSP	DEG_COP1_1	0.1389
p.D385N	DO47436	SKCM	ICGC	SSLEEVPSP	DEG_COP1_1	0.1389
p.D385N	DO223286	UCEC	ICGC	SSLEEVPSP	DEG_COP1_1	0.1389
p.E374K	TCGA-DU-6407	LGG	TCGA	SSLEEVPSP	DEG_COP1_1	0.591
p.E374K	DO22295	LGG	ICGC	SSLEEVPSP	DEG_COP1_1	0.591
p.S371I	TCGA-XC-AA0X	LUSC	TCGA	SSLEEVPSP	DEG_COP1_1	0.7341
p.S371I	DO52026	LUSC	ICGC	SSLEEVPSP	DEG_COP1_1	0.7341
p.S371I	SIDM00500	Colorectal Carcinoma	GDSC	SSLEEVPSP	DEG_COP1_1	0.7341
p.S371I	ACH-000959	Colon/Colorectal Cancer	CCLE	SSLEEVPSP	DEG_COP1_1	0.7341
p.V375A	DO229010	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	0.6936
p.V375A	DO229013	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	0.6936
p.V375A	DO229016	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	0.6936
p.V375A	DO229003	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	0.6936
p.V375A	DO229005	COCA	ICGC	SSLEEVPSP	DEG_COP1_1	0.6936
p.R380Q	DO234285	ESAD	ICGC	SSLEEVPSP	DEG_COP1_1	0.2778
p.A386V	SIDM01183	Other Solid Cancers	GDSC	SSLEEVPSP	DEG_COP1_1	0.1111
p.A386V	ACH-001417	Lung Cancer	CCLE	SSLEEVPSP	DEG_COP1_1	0.1111
p.A386V	UMC-11	lung	COSMIC	SSLEEVPSP	DEG_COP1_1	0.1111
p.V379M	SIDM01185	Other Solid Cancers	GDSC	SSLEEVPSP	DEG_COP1_1	0.3056
p.V379M	ACH-002204	Bone Cancer	CCLE	SSLEEVPSP	DEG_COP1_1	0.3056
p.V379M	U-CH2	bone	COSMIC	SSLEEVPSP	DEG_COP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSLEEVPSP

Degron related mutations and impact score

Drug responses associated with GPRIN2 mutations

All proteins holding degron of SSLEEVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_COP1_1	370:378	SSLEEVPSP	COP1	0.5751	More...