DegronMD - Q05952(TNP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R57C	TCGA-A5-A0G1	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1944
p.R57C	DO42472	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1944
p.P53L	TCGA-AX-A1C5	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0833
p.P53L	DO227752	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0833
p.P53L	DO41422	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0833
p.N58I	TCGA-CD-5801	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2222
p.N58I	DO38563	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2222
p.S65L	TCGA-EE-A2MM	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.S65L	DO222678	MELA	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.S65L	DO229459	SKCA	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.S65L	DO37770	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7667
p.T60A	TCGA-QG-A5Z1	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.T60A	DO51731	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.T60A	SIDM01878	Non-Cancerous	GDSC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.T60A	SIDM00053	Pancreatic Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.T60A	ACH-002360	Non-Cancerous	CCLE	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.P73T	DO223457	CLLE	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1389
p.S55R	DO228971	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1389
p.A54D	DO229029	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1111
p.H68N	DO229026	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.S64R	DO229041	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7427
p.R57H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1944
p.R57H	ACH-000960	Leukemia	CCLE	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1944
p.R57H	REH	haematopoietic and lymphoid tissue	COSMIC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1944
p.G67S	SIDM01763	Rhabdomyosarcoma	GDSC	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.3056
p.G67S	ACH-000079	Non-Cancerous	CCLE	AHSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.3056

Kaplan plot for TNP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNP2

UniProt ID: Q05952

Entrez ID: 7142

Protein name: Nuclear transition protein 2 (TP-2) (TP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNP2 in