DegronMD - Q6UVJ0(SASS6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G578A	TCGA-52-7810	LUSC	TCGA	DKENG	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.0556
p.G578A	TCGA-52-7810	LUSC	TCGA	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation rewiring degron network	0.0556
p.G578A	DO27381	LUSC	ICGC	DKENG	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.0556
p.G578A	DO27381	LUSC	ICGC	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation rewiring degron network	0.0556
p.T494A	TCGA-85-A512	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2222
p.P492H	TCGA-BP-5174	KIRC	TCGA	AHSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.T495P	TCGA-EO-A3AV	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	498:502	Mutation blocking phosphorylation signal	0.6944
p.L490F	TCGA-FS-A1ZW	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111
p.D488V	TCGA-HU-A4G8	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.D488V	DO47819	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.K589N	TCGA-MX-A5UJ	STAD	TCGA	DKENG	DEG_APCC_KENBOX_2	588:592	Mutation altering degron motif	0.6918
p.K589N	TCGA-MX-A5UJ	STAD	TCGA	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation altering degron motif	0.5806
p.H499P	DO228557	GACA	ICGC	AHSSS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.6583
p.G578R	SIDM02077	Colorectal Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.0556
p.G578R	SIDM02077	Colorectal Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation rewiring degron network	0.0556
p.E593K	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation altering degron motif	0.7022
p.E593K	ACH-000438	Lung Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation altering degron motif	0.7022
p.E593K	LU-65	lung	COSMIC	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation altering degron motif	0.7022
p.G596R	SIDM00905	Cervical Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2222
p.G596R	SIDM00905	Cervical Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation rewiring degron network	0.25
p.G596R	ACH-001334	Cervical Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2222
p.G596R	ACH-001334	Cervical Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation rewiring degron network	0.25
p.G596R	C-4-I	cervix	COSMIC	DKENG	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2222
p.G596R	C-4-I	cervix	COSMIC	DKENGE	DEG_Kelch_Keap1_1	588:593	Mutation rewiring degron network	0.25

Kaplan plot for SASS6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SASS6

UniProt ID: Q6UVJ0

Entrez ID: 163786

Protein name: Spindle assembly abnormal protein 6 homolog (HsSAS-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SASS6 in