DegronMD

Uniprot ID: Q6UVJ0

Source protein: Spindle assembly abnormal protein 6 homolog

Source gene: SASS6

Class: DEG_APCC_KENBOX_2

Location: 588:592

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8823

ASA_SCORE: 94.58

COIL: 0.8242

CONS_SCORE: 0.316

DSS_SCORE: 0.5001

HELIX: 0.1528

FCONS_SCORE: 0.9944

RIG_SCORE: 0.6747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G578A	TCGA-52-7810	LUSC	TCGA	DKENG	DEG_APCC_KENBOX_2	0.0556
p.G578A	DO27381	LUSC	ICGC	DKENG	DEG_APCC_KENBOX_2	0.0556
p.K589N	TCGA-MX-A5UJ	STAD	TCGA	DKENG	DEG_APCC_KENBOX_2	0.6918
p.G578R	SIDM02077	Colorectal Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	0.0556
p.G596R	SIDM00905	Cervical Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	0.2222
p.G596R	ACH-001334	Cervical Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	0.2222
p.G596R	C-4-I	cervix	COSMIC	DKENG	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95997	Securin	DEG_APCC_KENBOX_2	8:12	DKENG	APC,CDC20,FZR1	0.9977	More...
P55010	Eukaryotic translation initiation factor 5	DEG_APCC_KENBOX_2	167:171	DKENG	APC,CDC20,FZR1	0.6996	More...
Q6P1L5	Protein FAM117B	DEG_APCC_KENBOX_2	442:446	DKENG	APC,CDC20,FZR1	0.5729	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_APCC_KENBOX_2	588:592	DKENG	APC,CDC20,FZR1	0.8823	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_APCC_KENBOX_2	260:264	DKENG	APC,CDC20,FZR1	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons