DegronMD - P55010(EIF5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K160N	TCGA-A5-A0G2	UCEC	TCGA	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation substituting flanking lysine	0.25
p.K160N	DO41235	UCEC	ICGC	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation substituting flanking lysine	0.25
p.E177D	TCGA-AP-A1DV	UCEC	TCGA	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.1667
p.E177D	DO43186	UCEC	ICGC	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.1667
p.E159Q	TCGA-DK-A6B6	BLCA	TCGA	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.1111
p.E159Q	DO48576	BLCA	ICGC	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.1111
p.E177K	TCGA-DK-A6B6	BLCA	TCGA	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.1667
p.E177K	DO48576	BLCA	ICGC	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.1667
p.V173I	DO229055	LICA	ICGC	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.2778
p.S172F	SIDM00189	Melanoma	GDSC	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.3056
p.S172F	ACH-002098	Skin Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.3056
p.S172F	CP67-MEL	skin	COSMIC	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.3056
p.P179S	SIDM00487	Colorectal Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.1111
p.P179S	ACH-000963	Colon/Colorectal Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	167:171	Mutation rewiring degron network	0.1111

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons