DegronMD

Uniprot ID: P55010

Source protein: Eukaryotic translation initiation factor 5

Source gene: EIF5

Class: DEG_APCC_KENBOX_2

Location: 167:171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6996

ASA_SCORE: 107.62

COIL: 0.8394

CONS_SCORE: 0.2808

DSS_SCORE: 0.8122

HELIX: 0.136

FCONS_SCORE: 0.9244

RIG_SCORE: 0.4952

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K160N	TCGA-A5-A0G2	UCEC	TCGA	DKENG	DEG_APCC_KENBOX_2	0.25
p.K160N	DO41235	UCEC	ICGC	DKENG	DEG_APCC_KENBOX_2	0.25
p.E177D	TCGA-AP-A1DV	UCEC	TCGA	DKENG	DEG_APCC_KENBOX_2	0.1667
p.E177D	DO43186	UCEC	ICGC	DKENG	DEG_APCC_KENBOX_2	0.1667
p.E159Q	TCGA-DK-A6B6	BLCA	TCGA	DKENG	DEG_APCC_KENBOX_2	0.1111
p.E159Q	DO48576	BLCA	ICGC	DKENG	DEG_APCC_KENBOX_2	0.1111
p.E177K	TCGA-DK-A6B6	BLCA	TCGA	DKENG	DEG_APCC_KENBOX_2	0.1667
p.E177K	DO48576	BLCA	ICGC	DKENG	DEG_APCC_KENBOX_2	0.1667
p.V173I	DO229055	LICA	ICGC	DKENG	DEG_APCC_KENBOX_2	0.2778
p.S172F	SIDM00189	Melanoma	GDSC	DKENG	DEG_APCC_KENBOX_2	0.3056
p.S172F	ACH-002098	Skin Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	0.3056
p.S172F	CP67-MEL	skin	COSMIC	DKENG	DEG_APCC_KENBOX_2	0.3056
p.P179S	SIDM00487	Colorectal Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	0.1111
p.P179S	ACH-000963	Colon/Colorectal Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95997	Securin	DEG_APCC_KENBOX_2	8:12	DKENG	APC,CDC20,FZR1	0.9977	More...
P55010	Eukaryotic translation initiation factor 5	DEG_APCC_KENBOX_2	167:171	DKENG	APC,CDC20,FZR1	0.6996	More...
Q6P1L5	Protein FAM117B	DEG_APCC_KENBOX_2	442:446	DKENG	APC,CDC20,FZR1	0.5729	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_APCC_KENBOX_2	588:592	DKENG	APC,CDC20,FZR1	0.8823	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_APCC_KENBOX_2	260:264	DKENG	APC,CDC20,FZR1	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons