DegronMD - Q6P1L5(FAM117B)

FAM117B

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D435Y	TCGA-BS-A0UV	UCEC	TCGA	DKENG	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1389
p.Y454H	TCGA-FR-A8YC	SKCM	TCGA	DKENG	DEG_APCC_KENBOX_2	442:446	Mutation blocking phosphorylation signal	0.5556
p.P452L	TCGA-VQ-A8PP	STAD	TCGA	DKENG	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1667
p.H24D	DO44238	BRCA	ICGC	PTPAGS	DEG_SCF_FBW7_1	11:16	Mutation rewiring degron network	0.1111
p.K20N	DO228945	LICA	ICGC	PTPAGS	DEG_SCF_FBW7_1	11:16	Mutation rewiring degron network	0.2222
p.W12C	DO229015	LICA	ICGC	PTPAGS	DEG_SCF_FBW7_1	11:16	Mutation altering degron motif	0.7
p.A11P	DO47683	SKCM	ICGC	PTPAGS	DEG_SCF_FBW7_1	11:16	Mutation altering degron motif	0.7503
p.A25D	DO229268	THCA	ICGC	PTPAGS	DEG_SCF_FBW7_1	11:16	Mutation rewiring degron network	0.0833
p.G22R	DO41331	UCEC	ICGC	PTPAGS	DEG_SCF_FBW7_1	11:16	Mutation rewiring degron network	0.1667
p.T456A	SIDM01045	Endometrial Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	442:446	Mutation blocking phosphorylation signal	0.5
p.T456A	ACH-000978	Endometrial/Uterine Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	442:446	Mutation blocking phosphorylation signal	0.5
p.T456A	EN	endometrium	COSMIC	DKENG	DEG_APCC_KENBOX_2	442:446	Mutation blocking phosphorylation signal	0.5
p.A23V	ACH-000972	Endometrial/Uterine Cancer	CCLE	PTPAGS	DEG_SCF_FBW7_1	11:16	Mutation rewiring degron network	0.1389
p.A14T	ACH-000977	lymph node	CCLE	PTPAGS	DEG_SCF_FBW7_1	11:16	Mutation altering degron motif	0.6028

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*NOTE: the Kaplan plots were collected from OncoLnc