DegronMD

Uniprot ID: Q6P1L5

Source protein: Protein FAM117B

Source gene: FAM117B

Class: DEG_SCF_FBW7_1

Location: 11:16

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 75.9

COIL: 0.9227

CONS_SCORE: 0.356

DSS_SCORE: 0.6831

HELIX: 0.0283

FCONS_SCORE: 0.8572

RIG_SCORE: 0.56

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H24D	DO44238	BRCA	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.1111
p.K20N	DO228945	LICA	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.2222
p.W12C	DO229015	LICA	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.7
p.A11P	DO47683	SKCM	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.7503
p.A25D	DO229268	THCA	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.0833
p.G22R	DO41331	UCEC	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.1667
p.A23V	ACH-000972	Endometrial/Uterine Cancer	CCLE	PTPAGS	DEG_SCF_FBW7_1	0.1389
p.A14T	ACH-000977	lymph_node	CCLE	PTPAGS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P1L5	Protein FAM117B	DEG_SCF_FBW7_1	11:16	PTPAGS	FBXW7	0.9902	More...
O95081	Arf-GAP domain and FG repeat-containing protein 2	DEG_SCF_FBW7_1	289:294	PTPAGS	FBXW7	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons